Hamster Anti-IFNGR2 Recombinant Antibody (CBYY-I0346) (CBMAB-I0892-YY)

Name: Hamster Anti-IFNGR2 Recombinant Antibody (CBYY-I0346)
SKU: CBMAB-I0892-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Hamster

Clone

CBYY-I0346

Application

WB, FC, Neut, CyTOF

Specificity

Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.5 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interferon gamma receptor 2 (interferon gamma transducer 1)

Introduction

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

Entrez Gene ID

15980

UniProt ID

Q63953

Alternative Names

Interferon Gamma Receptor 2

Function

Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558).

Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148).

Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: Ensembl
Microglial cell activation Source: Ensembl
Positive regulation of NMDA glutamate receptor activity Source: Ensembl
Response to virus Source: ProtInc

Cellular Location

Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasm; Cell membrane; Cytoplasmic vesicle membrane. Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.

Involvement in disease

Immunodeficiency 28 (IMD28):
A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD28 is an autosomal recessive disease that manifests early in life, with severe, often fatal, infection.

Topology

Extracellular: 28-247
Helical: 248-268
Cytoplasmic: 269-337

Hong, Y., Heo, J., Kang, S., Vu, T. H., Lillehoj, H. S., & Hong, Y. H. (2023). Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14. Animal Bioscience, 36(6), 851.

Zhang, F., Peng, H., Fu, C., Deng, Y., Zhang, M., Li, W., ... & Zhao, J. (2023). Association Between HTRA1, GAS6 and IFNGR2 Gene Polymorphisms and Stroke Susceptibility in the Chinese Han Population. Pharmacogenomics and Personalized Medicine, 717-727.

Zhang, X., Chu, H., Cheng, Y., Ren, J., Wang, W., Liu, X., & Yan, X. (2023). Identification of RUNX1 and IFNGR2 as prognostic-related biomarkers correlated with immune infiltration and subtype differentiation of low-grade glioma. Biomolecules and Biomedicine, 23(3), 405.

Chen, X., Ren, X., E, J., Zhou, Y., & Bian, R. (2023). Exosome-transmitted circ IFNGR2 Modulates Ovarian Cancer Metastasis via miR-378/ST5 Axis. Molecular and cellular biology, 43(1), 22-42.

Xia, Y., Zhang, Q., Ye, Y., Wu, X., He, F., Peng, Y., ... & Ren, W. (2022). Melatonergic signalling instructs transcriptional inhibition of IFNGR2 to lessen interleukin‐1β‐dependent inflammation. Clinical and translational medicine, 12(2), e716.

Bhaladhare, A., Chauhan, A., Sonwane, A., Kumar, A., Kumar, P., Kumar, S., ... & Bhushan, B. (2020). Association of single nucleotide polymorphisms in IFNGR1 and IFNGR2 genes with bovine tuberculosis. Indian Journal of Animal Research, 54(1), 36-40.

Bandari, A. K., Muthusamy, B., Bhat, S., Govindaraj, P., Rajagopalan, P., Dalvi, A., ... & Pandey, A. (2019). A novel splice site mutation in IFNGR2 in patients with primary immunodeficiency exhibiting susceptibility to mycobacterial diseases. Frontiers in immunology, 10, 1964.

Yoo, I., Seo, H., Choi, Y., Jang, H., Han, J., Lee, S., ... & Ka, H. (2019). Analysis of interferon‐γ receptor IFNGR1 and IFNGR2 expression and regulation at the maternal‐conceptus interface and the role of interferon‐γ on endometrial expression of interferon signaling molecules during early pregnancy in pigs. Molecular Reproduction and Development, 86(12), 1993-2004.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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