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Mouse Anti-IFNL3 Recombinant Antibody (CBYY-I1614) (CBMAB-I2784-YY)

This product is Mouse antibody that recognizes IFNL3. The antibody CBYY-I1614 can be used for immunoassay techniques such as: ELISA, WB
See all IFNL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYY-I1614
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% NaN3
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Lambda 3
Introduction
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Entrez Gene ID
Human282617
Rat685840
UniProt ID
HumanQ8IZI9
RatF1M3K4
Alternative Names
Interferon Lambda 3
Function
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Biological Process
Defense response to virus Source: UniProtKB
Innate immune response Source: GO_Central
Negative regulation of viral genome replication Source: UniProtKB
Positive regulation of immune response Source: InterPro
Receptor signaling pathway via JAK-STAT Source: InterPro
Cellular Location
Secreted

Matic, S., Milovanovic, D., Mijailovic, Z., Djurdjevic, P., Sazdanovic, P., Stefanovic, S., ... & Djordjevic, N. (2023). IFNL3/4 polymorphisms as a two‐edged sword: An association with COVID‐19 outcome. Journal of Medical Virology, 95(2), e28506.

Rujescu, D., Herrling, M., Hartmann, A. M., Maul, S., Giegling, I., Konte, B., & Strupp, M. (2020). High-risk allele for herpes labialis severity at the IFNL3/4 locus is associated with vestibular neuritis. Frontiers in Neurology, 11, 570638.

Han, J. W., Sung, P. S., Hong, S. H., Lee, H., Koh, J. Y., Lee, H., ... & Shin, E. C. (2020). IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T cell frequency and increases virus-specific T cell responses. Journal of Hepatology, 73(1), 72-83.

Ghanem, S. E., Elsabaawy, M., Shebl, N., Abdelsameea, E., Othman, W., EL‑Bassal, F. I., ... & Helal, M. L. (2020). Value of IFNL3 genetic polymorphism in the prediction of HCV treatment response to direct-acting antiviral drugs versus interferon therapy. Expert Review of Anti-infective Therapy, 18(9), 947-954.

Peterson, S. T., Kennedy, E. A., Brigleb, P. H., Taylor, G. M., Urbanek, K., Bricker, T. L., ... & Baldridge, M. T. (2019). Disruption of type III interferon (IFN) genes Ifnl2 and Ifnl3 recapitulates loss of the type III IFN receptor in the mucosal antiviral response. Journal of virology, 93(22), 10-1128.

Metwally, M., Thabet, K., Bayoumi, A., Nikpour, M., Stevens, W., Sahhar, J., ... & Eslam, M. (2019). IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis. Scientific Reports, 9(1), 14834.

Zhao, Z., Qin, Z., Zhou, L., Xiang, L., You, J., Cao, R., ... & Li, M. (2019). The impact of IFNL3 genotype on interferon treatment outcome in patients chronically infected with hepatitis B virus: A meta-analysis. Microbial pathogenesis, 134, 103598.

Lindgren, M., Samuelsson, J., Nilsson, L., Knutsen, H., Ghanima, W., Westin, J., ... & Andréasson, B. (2018). Genetic variation in IL 28B (IFNL 3) and response to interferon‐alpha treatment in myeloproliferative neoplasms. European journal of haematology, 100(5), 419-425.

Frias, M., Rivero-Juárez, A., Rodriguez-Cano, D., Camacho, Á., López-López, P., Risalde, M. Á., ... & Rivero, A. (2018). HLA-B, HLA-C and KIR improve the predictive value of IFNL3 for Hepatitis C spontaneous clearance. Scientific Reports, 8(1), 659.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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