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Rabbit Anti-IGHG2 Recombinant Antibody (RM118) (CBMAB-BR292LY)

The product is antibody recognizes IGHG2. The antibody RM118 immunoassay techniques such as: ELISA.
See all IGHG2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
RM118
Antibody Isotype
IgG
Application
ELISA: 1-5 μg/ml

Basic Information

Immunogen
Human IgG2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 1% BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Immunoglobulin heavy constant gamma 2
Introduction
IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Immunoglobulin Kappa Light Chain Deficiency. Among its related pathways are Creation of C4 and C2 activators and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG3.
Entrez Gene ID
3501
UniProt ID
P01859
Alternative Names
Immunoglobulin heavy constant gamma 2 ;Ig gamma-2 chain C region ;Ig gamma-2 chain C region DOT ;Ig gamma-2 chain C region TIL ;Ig gamma-2 chain C region ZIE ;IGHG2 ;
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Biological Process
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Cellular Location
Secreted; Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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