Rabbit Anti-IGKC Recombinant Antibody (RM129) (CBMAB-BR298LY)

Name: Rabbit Anti-IGKC Recombinant Antibody (RM129)
SKU: CBMAB-BR298LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

RM129

Application

ELISA: 1-5 μg/ml

Immunogen

Human IgG

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol, 1% BSA

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Immunoglobulin Kappa Constant

Introduction

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include Immunoglobulin Kappa Light Chain Deficiency and Extramedullary Plasmacytoma. Among its related pathways are Immune response Fc epsilon RI pathway and Immune response Lectin induced complement pathway. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

Entrez Gene ID

3514

UniProt ID

P01834

Alternative Names

Immunoglobulin kappa constant ;Ig kappa chain C region ;Ig kappa chain C region AG ;Ig kappa chain C region CUM ;Ig kappa chain C region EU ;Ig kappa chain C region OU ;Ig kappa chain C region ROY ;Ig kappa chain C region TI ;IGKC ;

Function

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Biological Process

B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Retina homeostasis Source: UniProtKB

Cellular Location

Secreted; Cell membrane

Involvement in disease

Immunoglobulin kappa light chain deficiency (IGKCD):
A disease characterized by the complete absence of immunoglobulin kappa chains.

Onieva, J. L., Xiao, Q., Berciano-Guerrero, M. Á., Laborda-Illanes, A., De Andrea, C., Chaves, P., ... & Barragán, I. (2022). High IGKC-Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade. International Journal of Molecular Sciences, 23(16), 9124.

Schmidt, M., Edlund, K., Hengstler, J. G., Heimes, A. S., Almstedt, K., Lebrecht, A., ... & Joensuu, H. (2021). Prognostic impact of immunoglobulin kappa C (IGKC) in early breast cancer. Cancers, 13(14), 3626.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

IGKC Matched Antibody Pair (608) (CAT#: APMAB-608LY)

IGKC Matched Antibody Pair (609) (CAT#: APMAB-609LY)

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Rabbit Anti-IGKC Recombinant Antibody (RM126) (CAT#: CBMAB-BR300LY)

IGKC Matched Antibody Pair (608) (CAT#: APMAB-608LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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