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Mouse Anti-IKBIP Recombinant Antibody (2D5) (CBMAB-A4321-LY)

The product is antibody recognizes IKIP. The antibody 2D5 immunoassay techniques such as: WB, ELISA.
See all IKBIP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
IKIP (NP_710154.1, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IKBKB Interacting Protein
Entrez Gene ID
121457
UniProt ID
Q70UQ0
Alternative Names
FLJ31051
Function
Target of p53/TP53 with pro-apoptotic function.
Biological Process
Response to X-ray Source: BHF-UCL
Cellular Location
Endoplasmic reticulum membrane. Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.
Topology
Helical: 46-62
PTM
N-glycosylated. Isoform 4 is glycosylated at Asn-154.

Li, K., Huang, G., Wang, Z., Yang, R., Zhang, W., Ni, B., ... & Liu, Y. (2023). IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1869(1), 166571.

Chen, H., Liang, B., Luo, X., Zhang, W., Song, X., Lan, H., ... & Zhang, M. (2023). IKBIP might be a potential prognostic biomarker for glioblastoma multiforme. International Immunopharmacology, 118, 110030.

Zhang, H., Tang, R., Wen, X., Cai, J., Huang, J., Luo, L., & Yang, Z. (2023). Prognostic value of IKBIP in papillary renal cell carcinoma. BMC urology, 23(1), 121.

Li, Q., Zhao, Z., Pei, F., Kang, C., & Duan, F. (2023). IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies. Discovery Medicine, 35(174), 57-72.

Darmayanti, S., Lesmana, R., Meiliana, A., & Abdulah, R. (2023). V-ATPase subunit C 1 and IKBIP as Tandem Prospective Biomarkers for Diabetic Nephropathy. Diabetes Research and Clinical Practice, 110887.

Liang, J., Li, X., Xu, J., Cai, G. M., Cao, J. X., & Zhang, B. (2021). hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP. Aging (Albany NY), 13(23), 25213.

Yang, Y., Wang, J., Xu, S., Lv, W., Shi, F., & Shan, A. (2021). IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma. Translational neuroscience, 12(1), 009-019.

Lin, M., Liu, J., Shi, X., Li, J., & Ye, H. (2021). High IKBIP expression as a biomarker for poor prognosis and correlated with immune infiltrates in hepatocellular carcinoma (HCC).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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