Mouse Anti-IKZF5 Recombinant Antibody (1B6) (CBMAB-Z0688-WJ)

Name: Mouse Anti-IKZF5 Recombinant Antibody (1B6)
SKU: CBMAB-Z0688-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B6

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to AA2-101 from human ZNFN1A5 (NP_071911) with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

IKAROS family zinc finger 5

Introduction

IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is IKZF2.

Entrez Gene ID

64376

UniProt ID

Q9H5V7

Alternative Names

PEGASUS; ZNFN1A5

Function

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188).

Involved in megakaryocyte differentiation.

Biological Process

Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Thrombocytopenia 7 (THC7):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC7 is an autosomal dominant form with highly variable severity, ranging from absence of bleeding symptoms to epistaxis or more severe bleeding episodes.

Leinoe, E., Kjaersgaard, M., Zetterberg, E., Ostrowski, S., Greinacher, A., & Rossing, M. (2021). Highly impaired platelet ultrastructure in two families with novel IKZF5 variants. Platelets, 32(4), 492-497.

Lentaigne, C., Greene, D., Sivapalaratnam, S., Favier, R., Seyres, D., Thys, C., ... & Turro, E. (2019). Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood, The Journal of the American Society of Hematology, 134(23), 2070-2081.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-IKZF5 Recombinant Antibody (1B6) (CAT#: CBMAB-A10231-LY)

Related Products

Mouse Anti-IKZF5 Recombinant Antibody (1B6) (CAT#: CBMAB-A10231-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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