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Mouse Anti-IKZF5 Recombinant Antibody (1B6) (CBMAB-Z0688-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to AA2-101 from human ZNFN1A5 (NP_071911) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
IKAROS family zinc finger 5
Introduction
IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is IKZF2.
Entrez Gene ID
64376
UniProt ID
Q9H5V7
Alternative Names
PEGASUS; ZNFN1A5
Function
Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188).

Involved in megakaryocyte differentiation.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Thrombocytopenia 7 (THC7):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC7 is an autosomal dominant form with highly variable severity, ranging from absence of bleeding symptoms to epistaxis or more severe bleeding episodes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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