Mouse Anti-ILK Recombinant Antibody (CBYY-I2004) (CBMAB-I3174-YY)

integrin-linked kinase

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants.

Integrin Linked Kinase

Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715).
May act as a mediator of inside-out integrin signaling (PubMed:10712922).
Focal adhesion protein part of the complex ILK-PINCH (PubMed:10712922).
This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway (PubMed:10712922).
Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells (PubMed:10712922).
Regulates cell motility by forming a complex with PARVB (PubMed:32528174).
Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

Branching involved in ureteric bud morphogenesisIEA:Ensembl
Cell morphogenesisManual Assertion Based On ExperimentIMP:ARUK-UCL
Cell projection organizationIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of epithelial cell apical/basal polarityIEA:Ensembl
Fibroblast migrationIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of neural precursor cell proliferationIEA:Ensembl
Nerve developmentIEA:Ensembl
Outflow tract morphogenesisIEA:Ensembl
Peptidyl-serine phosphorylationIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of BMP signaling pathwayIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Protein kinase B signalingIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:CAFA

Cell membrane; Cytoplasm, myofibril, sarcomere

Autophosphorylated on serine residues.