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  • Rabbit Anti-ILKAP Recombinant Antibody (EG1652)

Rabbit Anti-ILKAP Recombinant Antibody (EG1652) (CBMAB-EN1977-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
EG1652
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human ILKAP.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
ILK associated serine/threonine phosphatase
Introduction
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
Entrez Gene ID
Human80895
Mouse67444
Rat64538
UniProt ID
HumanQ9H0C8
MouseQ8R0F6
RatQ9Z1Z6
Alternative Names
PP2CD; PPM1O; ILKAP2; ILKAP3; PP2C-DELTA
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Biological Process
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm

Liu, T., Liu, Y., Cao, J., Gao, X., Wang, J., Chen, G., ... & Zou, W. (2018). ILKAP binding to and dephosphorylating HIF-1α is essential for apoptosis induced by severe hypoxia. Cellular Physiology and Biochemistry, 46(6), 2500-2507.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ILKAP Recombinant Antibody (3B5) (CAT#: CBMAB-A4452-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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