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Rabbit Anti-IMMP2L Recombinant Antibody (D4R2F) (CBMAB-CP1169-LY)

The product is antibody recognizes IMMP2L. The antibody D4R2F immunoassay techniques such as: WB.
See all IMMP2L antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Rat
Clone
D4R2F
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP2 protein.
Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Inner Mitochondrial Membrane Peptidase Subunit 2
Introduction
This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
Entrez Gene ID
Human83943
Mouse93757
Rat100359529
Monkey701823
UniProt ID
HumanQ96T52
MouseQ8BPT6
MonkeyF6RN87
Alternative Names
Inner Mitochondrial Membrane Peptidase Subunit 2
Function
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Biological Process
Blood circulationIEA:Ensembl
Brain developmentIEA:Ensembl
Cellular response to DNA damage stimulusIEA:Ensembl
Cerebellum vasculature developmentIEA:Ensembl
Mitochondrial respiratory chain complex assemblyManual Assertion Based On ExperimentIBA:GO_Central
Ovarian follicle developmentIEA:Ensembl
OvulationIEA:Ensembl
Protein processing involved in protein targeting to mitochondrionBy SimilarityISS:UniProtKB
Respiratory electron transport chainIEA:Ensembl
Signal peptide processingIEA:InterPro
SpermatogenesisIEA:Ensembl
Superoxide metabolic processIEA:Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Gilles de la Tourette syndrome (GTS):
Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities.

Leung, B. K., Merlin, S., Walker, A. K., Lawther, A. J., Paxinos, G., Eapen, V., ... & Furlong, T. M. (2023). Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder. Behavioural Brain Research, 452, 114610.

Wang, Z., Xie, Y., Chen, H., Yao, J., Lv, L., Li, Y., ... & Liu, G. (2022). Guilingji protects against spermatogenesis dysfunction from oxidative stress via regulation of MAPK and apoptotic signaling pathways in Immp2l mutant mice. Frontiers in Pharmacology, 12, 771161.

Yoshikawa, A., Kushima, I., Miyashita, M., Suzuki, K., Iino, K., Toriumi, K., ... & Arai, M. (2022). Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype. Plos one, 17(7), e0270506.

Vasilyev, S. A., Skryabin, N. A., Kashevarova, A. A., Tolmacheva, E. N., Savchenko, R. R., Vasilyeva, O. Y., ... & Lebedev, I. N. (2021). Differential DNA methylation of the IMMP2L gene in families with maternally inherited 7q31. 1 microdeletions is associated with intellectual disability and developmental delay. Cytogenetic and Genome Research, 161(3-4), 105-119.

Bjerregaard, V. A., Schönewolf-Greulich, B., Juel Rasmussen, L., Desler, C., & Tümer, Z. (2020). Mitochondrial function in Gilles de la Tourette syndrome patients with and without intragenic IMMP2L deletions. Frontiers in Neurology, 11, 163.

He, Q., Gu, L., Lin, Q., Ma, Y., Liu, C., Pei, X., ... & Yang, Y. (2020). The Immp2l mutation causes ovarian aging through ROS-Wnt/β-catenin-estrogen pathway: preventive effect of melatonin. Endocrinology, 161(9), bqaa119.

Pagliaroli, L., Vereczkei, A., Padmanabhuni, S. S., Tarnok, Z., Farkas, L., Nagy, P., ... & Barta, C. (2020). Association of genetic variation in the 3'UTR of LHX6, IMMP2L, and AADAC with Tourette syndrome. Frontiers in Neurology, 11, 803.

Kreilaus, F., Chesworth, R., Eapen, V., Clarke, R., & Karl, T. (2019). First behavioural assessment of a novel Immp2l knockdown mouse model with relevance for Gilles de la Tourette syndrome and Autism spectrum disorder. Behavioural brain research, 374, 112057.

Zhang, Y., Liu, Y., Zarrei, M., Tong, W., Dong, R., Wang, Y., ... & Gai, Z. (2018). Association of IMMP2L deletions with autism spectrum disorder: A trio family study and meta‐analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(1), 93-100.

Yuan, L., Zhai, L., Qian, L., Huang, D., Ding, Y., Xiang, H., ... & Wang, X. F. (2018). Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. Cell Research, 28(6), 625-643.

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For research use only. Not intended for any clinical use.

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