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Mouse Anti-IMPDH1 Recombinant Antibody (3G6) (CBMAB-A4454-LY)

The product is antibody recognizes IMPDH1. The antibody 3G6 immunoassay techniques such as: WB, ELISA.
See all IMPDH1 antibodies
Published Data
Fig.1 Verification of the candidate targets.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
IMPDH1 (NP_000874, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IMP (inosine monophosphate) dehydrogenase 1
Introduction
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
3614
UniProt ID
P20839
Alternative Names
DKFZp781N0678; IMPD; IMPD1; LCA11; RP10; sWSS2608
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Biological Process
GMP biosynthetic processIEA:UniProtKB-UniRule
GTP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Retinitis pigmentosa 10 (RP10):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Leber congenital amaurosis 11 (LCA11):
A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.

Keppeke, G. D., Chang, C. C., Zhang, Z., & Liu, J. L. (2023). Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn. Frontiers in Cell and Developmental Biology, 11.

Sakti, D. H., Cornish, E. E., Nash, B. M., Jamieson, R. V., & Grigg, J. R. (2023). IMPDH1-associated autosomal dominant retinitis pigmentosa: natural history of novel variant Lys3124Gln and a comprehensive literature search. Ophthalmic Genetics, 1-19.

Liu, S. S., Li, J. S., Xue, M., Wu, W. J., Li, X., & Chen, W. (2023). LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2. International Journal of Biological Sciences, 19(8), 2599.

Burrell, A. L., Nie, C., Said, M., Simonet, J. C., Fernández-Justel, D., Johnson, M. C., ... & Kollman, J. M. (2022). IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Nature structural & molecular biology, 29(1), 47-58.

Liu, C., Zhang, W., Zhou, X., & Liu, L. (2022). IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma. Frontiers in Immunology, 13, 983490.

Andashti, B., Yazdanparast, R., Motahar, M., Barzegari, E., & Galehdari, H. (2021). Terminal peptide extensions augment the retinal IMPDH1 catalytic activity and attenuate the ATP-induced fibrillation events. Cell Biochemistry and Biophysics, 79, 221-229.

Shu, Q., Fan, Q., Hua, B., Liu, H., Wang, S., Liu, Y., ... & Ge, W. (2021). Influence of SLCO1B1 521T> C, UGT2B7 802C> T and IMPDH1− 106G> A genetic polymorphisms on mycophenolic acid levels and adverse reactions in chinese autoimmune disease patients. Pharmacogenomics and Personalized Medicine, 713-722.

Plana-Bonamaisó, A., López-Begines, S., Fernández-Justel, D., Junza, A., Soler-Tapia, A., Andilla, J., ... & Mendez, A. (2020). Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions. elife, 9, e56418.

Ruan, H., Song, Z., Cao, Q., Ni, D., Xu, T., Wang, K., ... & Chen, K. (2020). IMPDH1/YB-1 positive feedback loop assembles cytoophidia and represents a therapeutic target in metastatic tumors. Molecular Therapy, 28(5), 1299-1313.

Bennett, L. D., Klein, M., John, F. T., Radojevic, B., Jones, K., & Birch, D. G. (2020). Disease progression in patients with autosomal dominant retinitis pigmentosa due to a mutation in inosine monophosphate dehydrogenase 1 (IMPDH1). Translational Vision Science & Technology, 9(5), 14-14.

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For research use only. Not intended for any clinical use.

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