Sign in or Register   Sign in or Register
  |  

Recombinant Mouse Anti-Influenza B Neuraminidase Antibody (602) (CBMAB-MD866-LY)

The product is antibody recognizes Influenza B Virus. The antibody 602 immunoassay techniques such as: ELISA, Neut.
See all Influenza B Neuraminidase antibodies

Summary

Host Animal
Mouse
Specificity
Influenza B Virus
Clone
602
Antibody Isotype
IgM
Application
ELISA, Neut

Basic Information

Immunogen
Influenza B HK/73
Specificity
Influenza B Virus
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Influenza B Neuraminidase
Function
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
Biological Process
Carbohydrate metabolic processIEA:InterPro
Viral budding from plasma membraneIEA:UniProtKB-UniRule
Cellular Location
Virion membrane; Host apical cell membrane. Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Topology
Intravirion: 1-8
Helical: 9-31
Virion surface: 32-466
PTM
N-glycosylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Recombinant Mouse Anti-Influenza B Neuraminidase Antibody (602)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare