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Recombinant Mouse Anti-ING3 Recombinant Antibody (2A2) (CBMAB-XB0618-YC)

Provided herein is a Mouse Recombinant Antibody against Inhibitor Of Growth Family Member 3. The antibody can be used for immunoassay techniques, such as IHC, IF, IP, WB.
See all ING3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2A2
Antibody Isotype
IgG1
Application
IHC, IF, IP, WB

Basic Information

Immunogen
GST-fusion protein
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
inhibitor of growth family, member 3
Introduction
ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.
Entrez Gene ID
Human54556
Mouse71777
UniProt ID
HumanQ9NXR8
MouseQ8VEK6
Alternative Names
Inhibitor Of Growth Family Member 3
Function
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone H2A acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Regulation of growthIEA:UniProtKB-KW
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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