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Mouse Anti-ING4 Recombinant Antibody (8F7) (CBMAB-A4482-LY)

The product is antibody recognizes ING4. The antibody 8F7 immunoassay techniques such as: WB, ELISA.
See all ING4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8F7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ING4 (AAH07781.1, 1 a.a. ~ 249 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ING4
Introduction
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq]
Entrez Gene ID
51147
UniProt ID
Q9UNL4
Alternative Names
MGC12557; my036; p29ING4
Function
Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653).
Through chromatin acetylation it may function in DNA replication (PubMed:16387653).
May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276).
Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197).
May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197).
Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452).
Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cell cycleIEA:UniProtKB-KW
Chromatin organizationIEA:UniProtKB-KW
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K12 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone modificationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell cycle G2/M phase transitionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell growthManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Nucleus
PTM
Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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