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Mouse Anti-INHBA Recombinant Antibody (CBYY-I0633) (CBMAB-I1407-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0633
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients.
Entrez Gene ID
3624
UniProt ID
P08476
Alternative Names
Inhibin Beta A Subunit
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Biological Process
Activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Cellular response to cholesterolIEA:Ensembl
Cellular response to follicle-stimulating hormone stimulusIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:UniProtKB
Endodermal cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Erythrocyte differentiation1 PublicationNAS:UniProtKB
Extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Eyelid development in camera-type eyeISS:UniProtKB
GABAergic neuron differentiationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Hair follicle developmentManual Assertion Based On ExperimentIGI:UniProtKB
Hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Hemoglobin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Male gonad developmentManual Assertion Based On ExperimentIGI:UniProtKB
Mesodermal cell differentiationIEA:Ensembl
Negative regulation of B cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of follicle-stimulating hormone secretion1 PublicationNAS:UniProtKB
Negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of macrophage differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of phosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system development1 PublicationNAS:UniProtKB
OdontogenesisManual Assertion Based On ExperimentIGI:UniProtKB
Ovarian follicle developmentManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of erythrocyte differentiationManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of ovulationISS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Progesterone secretionManual Assertion Based On ExperimentIGI:UniProtKB
Regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIGI:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Roof of mouth developmentManual Assertion Based On ExperimentIGI:UniProtKB
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Striatal medium spiny neuron differentiationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular Location
Secreted
More Infomation

Liu, F., Liu, J., Shi, X., Hu, X., Wei, L., Huo, B., ... & Yang, L. (2023). Identification of INHBA as a potential biomarker for gastric cancer through a comprehensive analysis. Scientific Reports, 13(1), 12494.

Xiao, Q., Xiao, J., Liu, J., Liu, J., Shu, G., & Yin, G. (2022). Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction. Cell Death & Disease, 13(3), 202.

Qiu, S., Li, B., Xia, Y., Xuan, Z., Li, Z., Xie, L., ... & Xu, Z. (2022). CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA-and RBP-dependent manner. Cell death & disease, 13(3), 266.

Mouti, M. A., & Pauklin, S. (2021). TGFB1/INHBA homodimer/nodal-SMAD2/3 signaling network: a pivotal molecular target in PDAC treatment. Molecular Therapy, 29(3), 920-936.

Bao, Y., Yao, X., Li, X., Ei-Samahy, M. A., Yang, H., Liang, Y., ... & Wang, F. (2021). INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells. Theriogenology, 175, 111-122.

Li, X., Yu, W., Liang, C., Xu, Y., Zhang, M., Ding, X., & Cai, X. (2020). INHBA is a prognostic predictor for patients with colon adenocarcinoma. BMC cancer, 20, 1-10.

Zhang, C., Liang, Y., Ma, M. H., Wu, K. Z., & Dai, D. Q. (2019). KRT15, INHBA, MATN3, and AGT are aberrantly methylated and differentially expressed in gastric cancer and associated with prognosis. Pathology-Research and Practice, 215(5), 893-899.

Chen, Z. L., Qin, L., Peng, X. B., Hu, Y., & Liu, B. (2019). INHBA gene silencing inhibits gastric cancer cell migration and invasion by impeding activation of the TGF‐β signaling pathway. Journal of cellular physiology, 234(10), 18065-18074.

Lyu, S., Jiang, C., Xu, R., Huang, Y., & Yan, S. (2018). INHBA upregulation correlates with poorer prognosis in patients with esophageal squamous cell carcinoma. Cancer management and research, 1585-1596.

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For research use only. Not intended for any clinical use.

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