Mouse Anti-INPP5K Recombinant Antibody (3B4) (CBMAB-A4489-LY)

inositol polyphosphate-5-phosphatase K

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

PPS; SKIP

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732).
Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883).
Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity).

Cellular response to cAMPISS:UniProtKB
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hormone stimulusISS:UniProtKB
Cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to tumor necrosis factorManual Assertion Based On ExperimentIDA:UniProtKB
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathwayISS:UniProtKB
Glucose homeostasisISS:UniProtKB
In utero embryonic developmentIEA:Ensembl
Inositol phosphate dephosphorylationManual Assertion Based On ExperimentIDA:MGI
Negative regulation by host of viral transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of dephosphorylationISS:UniProtKB
Negative regulation of glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glycogen (starch) synthase activityISS:UniProtKB
Negative regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein phosphorylationISS:UniProtKB
Negative regulation of protein targeting to membraneManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediateManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of renal water transportISS:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Positive regulation of urine volumeISS:UniProtKB
Protein localization to plasma membraneISS:UniProtKB
Regulation of glycogen biosynthetic processISS:UniProtKB
Ruffle assemblyManual Assertion Based On ExperimentIDA:UniProtKB

Endoplasmic reticulum; Cytoplasm. Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976).
Concentrated at the periphery of the nucleus (PubMed:10753883).

Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID):
An autosomal recessive form of muscular dystrophy with onset in early childhood and characterized by progressive muscle weakness. Almost all patients also have early-onset cataracts and intellectual disability of varying severity. Some patients have seizures.