Rabbit Anti-INSL4 Recombinant Antibody (EG1654) (CBMAB-EN1982-LY)

The product is antibody recognizes INSL4. The antibody EG1654 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all INSL4 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1654

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human INSL4.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Insulin Like 4

Introduction

INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3641

UniProt ID

Q14641

Alternative Names

Insulin Like 4

Function

May play an important role in trophoblast development and in the regulation of bone formation.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of chorionic trophoblast cell proliferationManual Assertion Based On ExperimentTAS:GO_Central

Cellular Location

Secreted

References

Scopetti, D., Piobbico, D., Brunacci, C., Pieroni, S., Bellezza, G., Castelli, M., ... & Servillo, G. (2021). INSL4 as prognostic marker for proliferation and invasiveness in Non-Small-Cell Lung Cancer. Journal of Cancer, 12(13), 3781.

Scopetti, D., Piobbico, D., Brunacci, C., Pieroni, S., Bellezza, G., Castelli, M., ... & Servillo, G. (2020). Epigenetic control of INSL4 promotes cell growth and invasiveness in Non-Small-Cell Lung Cancer.

Yang, R., Li, S. W., Chen, Z., Zhou, X., Ni, W., Fu, D. A., ... & Wu, L. (2019). Role of INSL4 signaling in sustaining the growth and viability of LKB1-inactivated lung cancer. JNCI: Journal of the National Cancer Institute, 111(7), 664-674.

Yang, R., Li, S. W., Chen, Z., Zhou, X., Ni, W., Fu, D. A., ... & Wu, L. (2019). LKB-inactivated lung cancer cells exhibit dependency on INSL4 signaling. Cancer Research, 79(13_Supplement), 392-392.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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