Rabbit Anti-ITPKC Recombinant Antibody (EG1657) (CBMAB-EN1985-LY)

The product is antibody recognizes IP3KC. The antibody EG1657 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all ITPKC antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1657

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human IP3KC.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

inositol-trisphosphate 3-kinase C

Introduction

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.

Entrez Gene ID

80271

UniProt ID

Q96DU7

Alternative Names

IP3KC; IP3-3KC

Function

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.

Biological Process

Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm; Nucleus. Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.

References

Liu, J., Yuan, P., Pang, Y., & Su, D. (2023). ITPKC polymorphism (rs7251246 T> C), coronary artery aneurysms, and thrombosis in patients with Kawasaki disease in a Southern Han Chinese population. Frontiers in Immunology, 14, 1184162.

Bhattarai, D., Kumrah, R., Kaur, A., Kaur, A., Srivastava, P., Rawat, A., & Singh, S. (2022). Association of ITPKC gene polymorphisms rs28493229 and rs2290692 in North Indian children with Kawasaki disease. Pediatric Research, 92(4), 1090-1098.

Zhu, L., Zheng, Y., Wu, T., He, J., Fang, X., Zhou, S., ... & Wang, N. (2021). Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer. European Journal of Cancer Prevention, 30(5), 357-363.

Oshi, M., Newman, S., Murthy, V., Tokumaru, Y., Yan, L., Matsuyama, R., ... & Takabe, K. (2020). ITPKC as a prognostic and predictive biomarker of neoadjuvant chemotherapy for triple negative breast cancer. Cancers, 12(10), 2758.

Lu, H. F., Wong, H. S. C., Chen, B. K., Liao, H. T., Hsu, Y. W., Ikegawa, S., ... & Chang, W. C. (2018). Integrative genomic analysis for the functional roles of ITPKC in bone mineral density. Bioscience reports, 38(6), BSR20181481.

Kim, K. Y., Bae, Y. S., Ji, W., Shin, D., Kim, H. S., & Kim, D. S. (2018). ITPKC and SLC11A1 gene polymorphisms and gene-gene interactions in Korean patients with Kawasaki disease. Yonsei medical journal, 59(1), 119-127.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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