Mouse Anti-IP6K2 Recombinant Antibody (1C6) (CBMAB-A4497-LY)

Name: Mouse Anti-IP6K2 Recombinant Antibody (1C6)
SKU: CBMAB-A4497-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1C6

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

IP6K2 (NP_001005912.1, 1 a.a. ~ 70 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

inositol hexakisphosphate kinase 2

Introduction

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Entrez Gene ID

51447

UniProt ID

Q9UHH9

Alternative Names

IHPK2; PiUS

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).

Biological Process

Cellular response to flavonoidManual Assertion Based On ExperimentIMP:UniProtKB
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Inositol phosphate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Phosphate ion transportIEA:Ensembl
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus

More Infomation

References

Ito, M., Fujii, N., Kohara, S., Hori, S., Tanaka, M., Wittwer, C., ... & Nagata, E. (2023). Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system. Journal of Biological Chemistry, 299(3).

Ahn, M., Park, S. E., Choi, J., Choi, J., Choi, D., An, D., ... & Byun, Y. (2023). Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1), 2193866.

Sandström, J., Balian, A., Lockowandt, R., Fornander, T., Nordenskjöld, B., Lindström, L., ... & Stål, O. (2021). IP6K2 predicts favorable clinical outcome of primary breast cancer. Molecular and clinical oncology, 14(5), 1-10.

Balian, A., Lockowandt, R., Fornander, T., Nordenskjöld, B., Lindström, L., Pérez-Tenorio, G., & Stål, O. (2021). IP6K2 predicts favorable clinical outcome of primary breast cancer. Molecular and Clinical Oncology, 14(5).

Liang, R., & Tang, Y. (2020). LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis. Cancer Biomarkers, 28(2), 169-180.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-IP6K2 Recombinant Antibody (4F10)

Rabbit Anti-IP6K2 Recombinant Antibody (EG1658)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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