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Rabbit Anti-IPMK Recombinant Antibody (EG1662) (CBMAB-EN1990-LY)

The product is antibody recognizes IPMK. The antibody EG1662 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all IPMK antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1662
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human IPMK.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
inositol polyphosphate multikinase
Introduction
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19.
Entrez Gene ID
Human253430
Mouse69718
Rat171458
UniProt ID
HumanQ8NFU5
MouseQ7TT16
RatQ99NI4
Function
Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931).
Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931).
Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481).
Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892).
Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610).
Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
Biological Process
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Inositol phosphate metabolic processTAS:Reactome
Inositol trisphosphate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Necroptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus

Damstra‐Oddy, J. L., Warren, E. C., Perry, C. J., Desfougères, Y., Fitzpatrick, J. M. K., Schaf, J., ... & Williams, R. S. (2021). Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity. British Journal of Pharmacology, 178(5), 1149-1163.

Lee, B., Park, S. J., Hong, S., Kim, K., & Kim, S. (2021). Inositol polyphosphate multikinase signaling: multifaceted functions in health and disease. Molecules and Cells, 44(4), 187.

Laha, D., Portela-Torres, P., Desfougères, Y., & Saiardi, A. (2021). Inositol phosphate kinases in the eukaryote landscape. Advances in biological regulation, 79, 100782.

Yang, Z. L., Chen, J. N., Lu, Y. Y., Lu, M., Wan, Q. L., Wu, G. S., & Luo, H. R. (2021). Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans. Cell Calcium, 93, 102327.

Shears, S. B., & Wang, H. (2019). Inositol phosphate kinases: expanding the biological significance of the universal core of the protein kinase fold. Advances in biological regulation, 71, 118-127.

Tu-Sekine, B., Padhi, A., Jin, S., Kalyan, S., Singh, K., Apperson, M., ... & Kim, S. F. (2019). Inositol polyphosphate multikinase is a metformin target that regulates cell migration. The FASEB Journal, 33(12), 14137.

De Rango, F., Crocco, P., Iannone, F., Saiardi, A., Passarino, G., Dato, S., & Rose, G. (2019). Inositol polyphosphate multikinase (IPMK), a gene coding for a potential moonlighting protein, contributes to human female longevity. Genes, 10(2), 125.

Cestari, I., Anupama, A., & Stuart, K. (2018). Inositol polyphosphate multikinase regulation of Trypanosoma brucei life stage development. Molecular Biology of the Cell, 29(9), 1137-1152.

Saiardi, A., Azevedo, C., Desfougères, Y., Portela-Torres, P., & Wilson, M. S. (2018). Microbial inositol polyphosphate metabolic pathway as drug development target. Advances in biological regulation, 67, 74-83.

Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R. J., Guha, P., ... & Snyder, S. H. (2018). Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1α degradation. Circulation research, 122(3), 457-472.

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For research use only. Not intended for any clinical use.

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