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Mouse Anti-IQGAP3 Recombinant Antibody (6E3) (CBMAB-A4509-LY)

The product is antibody recognizes IQGAP3. The antibody 6E3 immunoassay techniques such as: WB, ELISA.
See all IQGAP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IQGAP3 (NP_839943, 602 a.a. ~ 698 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IQ motif containing GTPase activating protein 3
Entrez Gene ID
128239
UniProt ID
Q86VI3
Alternative Names
MGC10170; MGC10831; MGC1947
Biological Process
Cellular response to organic substanceIEA:Ensembl
ERK1 and ERK2 cascadeIEA:Ensembl
G1/S transition of mitotic cell cycleIEA:Ensembl
Negative regulation of gene expressionIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of mammary gland epithelial cell proliferationIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of protein phosphorylationIEA:Ensembl
Ras protein signal transductionIEA:Ensembl
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell sizeIEA:Ensembl
Regulation of GTPase activityIEA:InterPro
Cellular Location
Cell-cell junction; Cytoplasm; Cytosol; Lateral plasma membrane

Song, F., Dai, Q., Grimm, M. O., & Steinbach, D. (2023). The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers. Cancers, 15(4), 1115.

Mei, W., Dong, Y., Gu, Y., Kapoor, A., Lin, X., Su, Y., ... & Tang, D. (2023). IQGAP3 is relevant to prostate cancer: a detailed presentation of potential pathomechanisms. Journal of Advanced Research.

Hua, X., Long, Z. Q., Guo, L., Wen, W., Huang, X., Zhang, W. W., & Lin, H. X. (2021). IQGAP3 overexpression correlates with poor prognosis and radiation therapy resistance in breast cancer. Frontiers in Pharmacology, 11, 584450.

Leone, M., Cazorla-Vázquez, S., Ferrazzi, F., Wiederstein, J. L., Gründl, M., Weinstock, G., ... & Engel, F. B. (2021). IQGAP3, a YAP target, is required for proper cell-cycle progression and genome stability. Molecular Cancer Research, 19(10), 1712-1726.

Matsuo, J., Douchi, D., Myint, K., Mon, N. N., Yamamura, A., Kohu, K., ... & Ito, Y. (2021). Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. Gut, 70(10), 1833-1846.

Jinawath, N., Shiao, M. S., Chanpanitkitchote, P., Svasti, J., Furukawa, Y., & Nakamura, Y. (2020). Enhancement of migration and invasion of gastric cancer cells by IQGAP3. Biomolecules, 10(8), 1194.

Dongol, S., Zhang, Q., Qiu, C., Sun, C., Zhang, Z., Wu, H., & Kong, B. (2020). IQGAP3 promotes cancer proliferation and metastasis in high‑grade serous ovarian cancer. Oncology letters, 20(2), 1179-1192.

Liu, Z., Li, X., Ma, J., Li, D., Ju, H., Liu, Y., ... & Zhu, Y. (2020). Integrative analysis of the IQ motif-containing GTPase-activating protein family indicates that the IQGAP3-PIK3C2B axis promotes invasion in colon cancer. OncoTargets and therapy, 8299-8311.

Lin, M., Liu, Y., Ding, X., Ke, Q., Shi, J., Ma, Z., ... & Ye, M. (2019). E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation. American journal of cancer research, 9(2), 285.

Oue, N., Yamamoto, Y., Oshima, T., Asai, R., Ishikawa, A., Uraoka, N., ... & Yasui, W. (2018). Overexpression of the transmembrane protein IQGAP3 is associated with poor survival of patients with gastric cancer. Pathobiology, 85(3), 192-200.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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