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Rat Anti-ISM1 Recombinant Antibody (CBYY-I0847) (CBMAB-I1937-YY)

This product is Rat antibody that recognizes ISM1. The antibody CBYY-I0847 can be used for immunoassay techniques such as: WB
See all ISM1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Human
Clone
CBYY-I0847
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.05% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Isthmin 1
Introduction
ISM1 (Isthmin 1) is a Protein Coding gene. Diseases associated with ISM1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. An important paralog of this gene is ISM3.
Entrez Gene ID
Human140862
Mouse319909
UniProt ID
HumanB1AKI9
MouseA2ATD1
Alternative Names
Isthmin 1
Function
Acts as an angiogenesis inhibitor.
Biological Process
Negative regulation of angiogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted

Sahiri, V., Caron, J., Roger, E., Desterke, C., Ghachem, K., Mohamadou, I., ... & Boffa, J. J. (2023). The Angiogenesis Inhibitor Isthmin-1 (ISM1) Is Overexpressed in Experimental Models of Glomerulopathy and Impairs the Viability of Podocytes. International Journal of Molecular Sciences, 24(3), 2723.

Menghuan, L., Yang, Y., Qianhe, M., Na, Z., Shicheng, C., Bo, C., & XueJie, Y. I. (2023). Advances in research of biological functions of Isthmin-1. Journal of Cell Communication and Signaling, 1-15.

Gao, G., Li, X., Jiang, Z., Osorio, L., Tang, Y. L., Yu, X., ... & Zhou, Z. (2023). Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development. Nature Communications, 14(1), 2378.

Liao, J., Li, Y., Gui, X., Zhang, Y., Hu, X., Cheng, L., ... & Bai, F. (2023). Serum Isthmin-1 Was Increased in Type 2 Diabetic Patients but Not in Diabetic Sensorimotor Peripheral Neuropathy. Diabetes, Metabolic Syndrome and Obesity, 2013-2024.

Nguyen, N., Xu, S., Lam, T. Y. W., Liao, W., Wong, W. F., & Ge, R. (2022). ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice. Molecular Medicine, 28(1), 72.

Yoshimoto, S., Katayama, K., Suzuki, T., Dohmae, N., & Simizu, S. (2021). Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation. Biochimica et Biophysica Acta (BBA)-General Subjects, 1865(3), 129840.

Jiang, Z., Zhao, M., Voilquin, L., Jung, Y., Aikio, M. A., Sahai, T., ... & Svensson, K. J. (2021). Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell metabolism, 33(9), 1836-1852.

Lansdon, L. A., Darbro, B. W., Petrin, A. L., Hulstrand, A. M., Standley, J. M., Brouillette, R. B., ... & Manak, J. R. (2018). Identification of Isthmin 1 as a novel clefting and craniofacial patterning gene in humans. Genetics, 208(1), 283-296.

Berrun, A., Harris, E., & Stachura, D. L. (2018). Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish. PLoS One, 13(5), e0196872.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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