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Mouse Anti-ITGA2 Antibody (P1H5) (CBMAB-0095-YC)

Provided herein are mouse monoclonal antibodies against Human ITGA2. The antibody clone P1H5 can be used for immunoassay techniques, such as WB.
See all ITGA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
P1H5
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Subunit Alpha 2
Introduction
The ITGA2 protein is an integrin alpha subunit, a transmembrane receptor for collagens and related proteins. It makes up half of the α2β1 integrin duplex. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia.
Entrez Gene ID
UniProt ID
Alternative Names
BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2
Function
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIMP:UniProtKB
Cell population proliferationIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to estradiol stimulusIEA:Ensembl
Cellular response to mechanical stimulusIEA:Ensembl
Collagen-activated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Detection of mechanical stimulus involved in sensory perception of painIEA:Ensembl
Establishment of protein localizationIEA:Ensembl
Female pregnancyIEA:Ensembl
Focal adhesion assemblyIEA:Ensembl
Hepatocyte differentiationIEA:Ensembl
Hypotonic responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland developmentIEA:Ensembl
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of cell adhesionIEA:Ensembl
Positive regulation of cell projection organizationIEA:Ensembl
Positive regulation of collagen bindingIEA:Ensembl
Positive regulation of collagen biosynthetic processIEA:Ensembl
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of epithelial cell migrationIEA:Ensembl
Positive regulation of inflammatory responseIEA:Ensembl
Positive regulation of leukocyte migrationIEA:Ensembl
Positive regulation of phagocytosis, engulfmentIEA:Ensembl
Positive regulation of positive chemotaxisIEA:Ensembl
Positive regulation of smooth muscle cell migrationIEA:Ensembl
Positive regulation of smooth muscle cell proliferationIEA:Ensembl
Positive regulation of smooth muscle contractionIEA:Ensembl
Positive regulation of translationIEA:Ensembl
Positive regulation of transmission of nerve impulseIEA:Ensembl
Response to amineIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to L-ascorbic acidIEA:Ensembl
Response to muscle activityIEA:Ensembl
Response to parathyroid hormoneIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Skin morphogenesisIEA:Ensembl
Substrate-dependent cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 30-1132
Helical: 1133-1154
Cytoplasmic: 1155-1181

Zhou, C., Li, S., Bin, K., Qin, G., Pan, P., Ren, D., ... & Zhou, Y. (2022). ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer. Cancer Letters, 547, 215855.

Islam, S., Kitagawa, T., Baron, B., Abiko, Y., Chiba, I., & Kuramitsu, Y. (2021). ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis. Scientific reports, 11(1), 10563.

Huang, W., Zhu, J., Shi, H., Wu, Q., & Zhang, C. (2021). ITGA2 overexpression promotes esophageal squamous cell carcinoma aggression via FAK/AKT signaling pathway. OncoTargets and therapy, 3583-3596.

Adorno-Cruz, V., Hoffmann, A. D., Liu, X., Dashzeveg, N. K., Taftaf, R., Wray, B., ... & Liu, H. (2021). ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis. Genes & diseases, 8(4), 493-508.

Gaballa, R., Ali, H. E., Mahmoud, M. O., Rhim, J. S., Ali, H. I., Salem, H. F., ... & Abd Elmageed, Z. Y. (2020). Exosomes-mediated transfer of Itga2 promotes migration and invasion of prostate cancer cells by inducing epithelial-mesenchymal transition. Cancers, 12(8), 2300.

Ma, L., Sun, Y., Li, D., Li, H., Jin, X., & Ren, D. (2020). Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway. Aging (Albany NY), 12(6), 5336.

Wang, S., Liu, X., Khan, A. A., Li, H., Tahir, M., Yan, X., ... & Huang, H. (2020). miR-216a-mediated upregulation of TSPAN1 contributes to pancreatic cancer progression via transcriptional regulation of ITGA2. American journal of cancer research, 10(4), 1115.

Guo, P., Moses-Gardner, A., Huang, J., Smith, E. R., & Moses, M. A. (2019). ITGA2 as a potential nanotherapeutic target for glioblastoma. Scientific reports, 9(1), 6195.

Ren, D., Zhao, J., Sun, Y., Li, D., Meng, Z., Wang, B., ... & Wu, H. (2019). Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-18.

Chuang, Y. C., Wu, H. Y., Lin, Y. L., Tzou, S. C., Chuang, C. H., Jian, T. Y., ... & Liao, K. W. (2018). Blockade of ITGA2 induces apoptosis and inhibits cell migration in gastric cancer. Biological procedures online, 20, 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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