Mouse Anti-ITGA8 Recombinant Antibody (2G7) (CBMAB-A4578-LY)

Name: Mouse Anti-ITGA8 Recombinant Antibody (2G7)
SKU: CBMAB-A4578-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2G7

Antibody Isotype

IgG2b, κ

Application

WB, ELISA

Basic Information

Immunogen

ITGA8 (NP_003629, 836 a.a. ~ 935 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

integrin alpha 8

Entrez Gene ID

8516

UniProt ID

P53708

Function

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Biological Process

Brain developmentIEA:Ensembl
Cell projection organizationIEA:Ensembl
Cell-cell adhesion1 PublicationNAS:UniProtKB
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Establishment of protein localizationIEA:Ensembl
Extracellular matrix organizationIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Kidney developmentManual Assertion Based On ExperimentIMP:UniProtKB
MemoryIEA:Ensembl
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Metanephros developmentIEA:Ensembl
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIEA:Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Smooth muscle tissue developmentIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane; Cell membrane

Involvement in disease

Renal hypodysplasia/aplasia 1 (RHDA1):
A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.

Topology

Extracellular: 39-1012
Helical: 1013-1033
Cytoplasmic: 1034-1063

More Infomation

References

Ma, X., Zhang, L., Liu, L., Ruan, D., & Wang, C. (2023). Hypermethylated ITGA8 Facilitate Bladder Cancer Cell Proliferation and Metastasis. Applied Biochemistry and Biotechnology, 1-16.

Li, X., Zhu, G., Li, Y., Huang, H., Chen, C., Wu, D., ... & Chen, J. (2023). LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma. Frontiers in Immunology, 14, 1096818.

Warthi, G., Faulkner, J. L., Doja, J., Ghanam, A. R., Gao, P., Yang, A. C., ... & Miano, J. M. (2022). Generation and comparative analysis of an itga8-CreER T2 mouse with preferential activity in vascular smooth muscle cells. Nature cardiovascular research, 1(11), 1084-1100.

Wang, Y., Wang, W., Yang, X., Chen, W., Yang, X., Pan, X., ... & Chen, X. (2021). ITGA8 positive cells in the conventional outflow tissue exhibit Schlemm's canal endothelial cell properties. Life Sciences, 278, 119564.

Marek, I., Hilgers, K. F., Rascher, W., Woelfle, J., & Hartner, A. (2020). A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney. Molecular and Cellular Pediatrics, 7(1), 1-4.

Wu, H. C., Chen, C. M., Chen, Y. C., Fung, H. C., Chang, K. H., & Wu, Y. R. (2018). DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging, 64, 158-e1.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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