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Mouse Anti-ITGB4 Recombinant Antibody (CBYY-C0659) (CBMAB-C1951-YY)

This product is mouse antibody that recognizes ITGB4. The antibody CBYY-C0659 can be used for immunoassay techniques such as: FC, WB
See all ITGB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C0659
Antibody Isotype
IgG2a
Application
FC, WB

Basic Information

Immunogen
UM-SCC-1, human squamous cell carcinoma
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
1 mg/mL
Preservative
PBS
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Subunit Beta 4
Entrez Gene ID
3691
UniProt ID
P16144
Alternative Names
AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p, C3
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
Biological Process
AutophagyManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesion1 PublicationNAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Filopodium assemblyIEA:Ensembl
Hemidesmosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Nail developmentManual Assertion Based On ExperimentIMP:UniProtKB
Peripheral nervous system myelin formationIEA:Ensembl
Response to woundingManual Assertion Based On ExperimentIDA:UniProtKB
Skin morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Trophoblast cell migrationIEA:Ensembl
Cellular Location
Cell membrane; Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Involvement in disease
Epidermolysis bullosa letalis, with pyloric atresia (EB-PA):
An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Generalized atrophic benign epidermolysis bullosa (GABEB):
A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Topology
Extracellular: 28-710
Helical: 711-733
Cytoplasmic: 734-1822
PTM
Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins.

Jiang, X., Wang, J., Wang, M., Xuan, M., Han, S., Li, C., ... & Zhao, Z. (2021). ITGB4 as a novel serum diagnosis biomarker and potential therapeutic target for colorectal cancer. Cancer Medicine, 10(19), 6823-6834.

Huang, W., Fan, L., Tang, Y., Chi, Y., & Li, J. (2021). A pan-cancer analysis of the oncogenic role of integrin Beta4 (ITGB4) in human Tumors. International Journal of General Medicine, 9629-9645.

Sung, J. S., Kang, C. W., Kang, S., Jang, Y., Chae, Y. C., Kim, B. G., & Cho, N. H. (2020). ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts. Oncogene, 39(3), 664-676.

Meng, X., Liu, P., Wu, Y., Liu, X., Huang, Y., Yu, B., ... & Tan, X. (2020). Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway. Bosnian Journal of Basic Medical Sciences, 20(1), 106.

Wilkinson, E. J., Woodworth, A. M., Parker, M., Phillips, J. L., Malley, R. C., Dickinson, J. L., & Holloway, A. F. (2020). Epigenetic regulation of the ITGB4 gene in prostate cancer. Experimental cell research, 392(2), 112055.

Li, M., Jiang, X., Wang, G., Zhai, C., Liu, Y., Li, H., ... & Zhao, Z. (2019). ITGB4 is a novel prognostic factor in colon cancer. Journal of Cancer, 10(21), 5223.

Wu, P., Wang, Y., Wu, Y., Jia, Z., Song, Y., & Liang, N. (2019). Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ, 7, e8299.

Yuan, L., Du, X., Tang, S., Wu, S., Wang, L., Xiang, Y., ... & Liu, C. (2019). ITGB 4 deficiency induces senescence of airway epithelial cells through p53 activation. The FEBS Journal, 286(6), 1191-1203.

Hong, D., Zhang, X., Li, R., Yu, J., Lou, Y., He, Q., ... & Chen, Y. (2019). Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway. Cell Death & Differentiation, 26(8), 1453-1466.

Liu, C., Yuan, L., Zou, Y., Yang, M., Chen, Y., Qu, X., ... & Qin, X. (2018). ITGB4 is essential for containing HDM-induced airway inflammation and airway hyperresponsiveness. Journal of leukocyte biology, 103(5), 897-908.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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