Mouse Anti-IVD Recombinant Antibody (CBYY-I1898) (CBMAB-I3068-YY)

Name: Mouse Anti-IVD Recombinant Antibody (CBYY-I1898)
SKU: CBMAB-I3068-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-I1898

Application

WB, IHC, IF, FC

Immunogen

Full length human recombinant protein of human IVD (NP_002612)

Specificity

Human, Dog, Rat, Monkey

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Isovaleryl-CoA Dehydrogenase

Introduction

Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene.

Entrez Gene ID

Human	3712
Rat	24513
Monkey	702867
Dog	100856316

UniProt ID

Human	P26440
Rat	P12007
Monkey	A0A2K5VT56
Dog	E2RRP1

Alternative Names

Isovaleryl-CoA Dehydrogenase

Function

Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway (PubMed:7640268).
To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA (PubMed:7640268).

Biological Process

Branched-chain amino acid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Fatty acid beta-oxidation using acyl-CoA dehydrogenaseManual Assertion Based On ExperimentIDA:BHF-UCL
Leucine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion matrix

Involvement in disease

Isovaleric acidemia (IVA):
A metabolic disorder characterized by retarded psychomotor development, a peculiar odor resembling sweaty feet, an aversion to dietary protein, and pernicious vomiting, leading to acidosis and coma. The acute neonatal form leads to massive metabolic acidosis from the first days of life and rapid death.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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