Mouse Anti-JCAD Recombinant Antibody (CBLY1-033) (CBMAB-K0394-LY)

Name: Mouse Anti-JCAD Recombinant Antibody (CBLY1-033)
SKU: CBMAB-K0394-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLY1-033

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

junctional cadherin 5 associated

Introduction

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution.

Entrez Gene ID

Human	57608
Mouse	240185
Rat	498764

UniProt ID

Human	Q9P266
Mouse	Q5DTX6
Rat	F1M6T3

Alternative Names

KIAA1462

Biological Process

Cell adhesionIEA:UniProtKB-KW
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sprouting angiogenesisIEA:Ensembl
Positive regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell junction, adherens junction. Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells.

Hiraoka, Y., Matsumura, M., Kakei, Y., Takeda, D., Shigeoka, M., Kimoto, A., ... & Akashi, M. (2023). Expression of JCAD and EGFR in Perineurial Cell–Cell Junctions of Human Inferior Alveolar Nerve. Journal of Histochemistry & Cytochemistry, 00221554231182193.

Liberale, L., Puspitasari, Y. M., Ministrini, S., Akhmedov, A., Kraler, S., Bonetti, N. R., ... & Camici, G. G. (2023). JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. European Heart Journal, 44(20), 1818-1833.

Guzik, T. J., & Channon, K. M. (2023). JCAD: a new GWAS target to reduce residual cardiovascular risk?. European Heart Journal, 44(20), 1834-1836.

Shigeoka, M., Arimoto, S., & Akashi, M. (2020). JCAD expression and localization in human blood endothelial cells. Heliyon, 6(10).

Douglas, G., Mehta, V., Al Haj Zen, A., Akoumianakis, I., Goel, A., Rashbrook, V. S., ... & Channon, K. M. (2020). A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Cardiovascular research, 116(11), 1863-1874.

Xu, S., Xu, Y., Liu, P., Zhang, S., Liu, H., Slavin, S., ... & Jin, Z. G. (2019). The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. European heart journal, 40(29), 2398-2408.

Jones, P. D., Kaiser, M. A., Ghaderi Najafabadi, M., Koplev, S., Zhao, Y., Douglas, G., ... & Webb, T. R. (2018). JCAD, a gene at the 10p11 coronary artery disease locus, regulates hippo signaling in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 38(8), 1711-1722.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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