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Mouse Anti-JCAD Recombinant Antibody (CBLY1-033) (CBMAB-K0394-LY)

This product is antibody recognizes JCAD. The antibody CBLY1-033 immunoassay techniques such as: WB, IP, IF, ELISA.
See all JCAD antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBLY1-033
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
junctional cadherin 5 associated
Introduction
This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution.
Entrez Gene ID
Human57608
Mouse240185
Rat498764
UniProt ID
HumanQ9P266
MouseQ5DTX6
RatF1M6T3
Alternative Names
KIAA1462
Biological Process
Cell adhesionIEA:UniProtKB-KW
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sprouting angiogenesisIEA:Ensembl
Positive regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell junction, adherens junction. Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells.

Hiraoka, Y., Matsumura, M., Kakei, Y., Takeda, D., Shigeoka, M., Kimoto, A., ... & Akashi, M. (2023). Expression of JCAD and EGFR in Perineurial Cell–Cell Junctions of Human Inferior Alveolar Nerve. Journal of Histochemistry & Cytochemistry, 00221554231182193.

Liberale, L., Puspitasari, Y. M., Ministrini, S., Akhmedov, A., Kraler, S., Bonetti, N. R., ... & Camici, G. G. (2023). JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. European Heart Journal, 44(20), 1818-1833.

Guzik, T. J., & Channon, K. M. (2023). JCAD: a new GWAS target to reduce residual cardiovascular risk?. European Heart Journal, 44(20), 1834-1836.

Shigeoka, M., Arimoto, S., & Akashi, M. (2020). JCAD expression and localization in human blood endothelial cells. Heliyon, 6(10).

Douglas, G., Mehta, V., Al Haj Zen, A., Akoumianakis, I., Goel, A., Rashbrook, V. S., ... & Channon, K. M. (2020). A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Cardiovascular research, 116(11), 1863-1874.

Xu, S., Xu, Y., Liu, P., Zhang, S., Liu, H., Slavin, S., ... & Jin, Z. G. (2019). The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. European heart journal, 40(29), 2398-2408.

Jones, P. D., Kaiser, M. A., Ghaderi Najafabadi, M., Koplev, S., Zhao, Y., Douglas, G., ... & Webb, T. R. (2018). JCAD, a gene at the 10p11 coronary artery disease locus, regulates hippo signaling in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 38(8), 1711-1722.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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