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Mouse Anti-JDP2 Recombinant Antibody (CBFYJ-025) (CBMAB-0038-FY)

This product is mouse antibody that recognizes JDP2. The antibody CBFYJ-025 can be used for immunoassay techniques such as: WB, ELISA.
See all JDP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYJ-025
Antibody Isotype
IgG2a, Κ
Application
WB, ELISA

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 Kda.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-163

Target

Full Name
Jun dimerization protein 2
Introduction
JDP2 (Jun Dimerization Protein 2) is a Protein Coding gene. Diseases associated with JDP2 include Skeletal Muscle Cancer. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and ATF-2 transcription factor network. An important paralog of this gene is ATF3. Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Entrez Gene ID
UniProt ID
Alternative Names
JDP2; Jun dimerization protein 2; jun dimerization protein 2; JUNDM2; progesterone receptor co activator; progesterone receptor co-activator
Function
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Biological Process
Negative regulation of fat cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of histone deacetylationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.
Polyubiquitinated; probably by IRF2BP1.

Li, S., Chen, Y., Jia, Y., Xue, T., Hou, X., & Zhao, Z. (2022). Transcription factor JDP2 activates PDE4B to participate in hypoxia/reoxygenation‑induced H9c2 cell injury. Experimental and Therapeutic Medicine, 23(5), 1-10.

Nakane, T., Matsumoto, S., Iida, S., Ido, A., Fukunaga, K., Murao, K., & Sugiyama, Y. (2021). Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 β-cells. Molecular and Cellular Endocrinology, 527, 111240.

Euler, G., Kockskämper, J., Schulz, R., & Parahuleva, M. S. (2021). JDP2, a Novel Molecular Key in Heart Failure and Atrial Fibrillation?. International Journal of Molecular Sciences, 22(8), 4110.

Xu, Y., Xia, X., Jiang, Y., Wu, D., Wang, S., Fu, S., ... & Sun, L. (2020). Down‐regulated lncRNA AGAP2‐AS1 contributes to pre‐eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype. Journal of Cellular and Molecular Medicine, 24(8), 4557-4568.

Engler, M. J., Mimura, J., Yamazaki, S., & Itoh, K. (2020). JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis. FEBS Open bio, 10(12), 2771-2779.

Kalfon, R., Friedman, T., Eliachar, S., Shofti, R., Haas, T., Koren, L., ... & Aronheim, A. (2019). JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function. PLoS One, 14(2), e0213081.

Boasman, K., Simmonds, M. J., Graham, C., Saunthararajah, Y., & Rinaldi, C. R. (2019). Using PU. 1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation. Annals of Hematology, 98, 1529-1531.

Avraham, S., Korin, B., Aviram, S., Shechter, D., Shaked, Y., & Aronheim, A. (2019). ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription. Oncogene, 38(20), 3812-3823.

Heger, J., Bornbaum, J., Würfel, A., Hill, C., Brockmann, N., Gáspár, R., ... & Euler, G. (2018). JDP2 overexpression provokes cardiac dysfunction in mice. Scientific Reports, 8(1), 7647.

Wang, X. H., Liu, Q., & Shao, Z. T. (2018). Deletion of JDP2 improves neurological outcomes of traumatic brain injury (TBI) in mice: inactivation of Caspase-3. Biochemical and biophysical research communications, 504(4), 805-811.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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