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Mouse Anti-JMJD6 Recombinant Antibody (A723) (CBMAB-AP4051LY)


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Summary

Host Animal
Mouse
Specificity
Dog, Human, Mouse, Rat
Clone
A723
Antibody Isotype
IgG
Application
ELISA, ICC, WB

Basic Information

Immunogen
Recombinant fragment, corresponding to amino acids 11-248aa of human JMJD6(N-terminus).
Specificity
Dog, Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
Human23210
Mouse107817
Rat360665
Dog100856152
UniProt ID
HumanQ6NYC1
MouseQ9ERI5
RatQ6AYK2
DogA0A5F4CKN0
Function
CSB-MA184549
Biological Process
Cell surface receptor signaling pathwayIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Erythrocyte developmentIEA:Ensembl
Heart developmentIEA:Ensembl
Histone H3-R2 demethylationManual Assertion Based On ExperimentIDA:BHF-UCL
Histone H4-R3 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Kidney developmentIEA:Ensembl
Lung developmentIEA:Ensembl
Macrophage activationIEA:Ensembl
mRNA processingIEA:UniProtKB-KW
Oxidative RNA demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-lysine hydroxylation to 5-hydroxy-L-lysineManual Assertion Based On ExperimentIDA:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Protein demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Recognition of apoptotic cellIEA:Ensembl
Regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIMP:UniProtKB
Retina development in camera-type eyeIEA:Ensembl
RNA splicingIEA:UniProtKB-KW
Sprouting angiogenesisISS:UniProtKB
T cell differentiation in thymusIEA:Ensembl
Cellular Location
Nucleus, nucleoplasm; Nucleus, nucleolus; Cytoplasm. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
PTM
Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
More Infomation

Xiao, R. Q., Ran, T., Huang, Q. X., Hu, G. S., Fan, D. M., Yi, J., & Liu, W. (2022). A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo. Proceedings of the National Academy of Sciences, 119(34), e2200753119.

Wang, K., Yang, C., Li, H., Liu, X., Zheng, M., Xuan, Z., ... & Wang, H. (2022). Role of the epigenetic modifier JMJD6 in tumor development and regulation of immune response. Frontiers in immunology, 13, 859893.

Paschalis, A., Welti, J., Neeb, A. J., Yuan, W., Figueiredo, I., Pereira, R., ... & de Bono, J. S. (2022). JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer. Cancer research, 81(4), 1087-1100.

Cockman, M. E., Sugimoto, Y., Pegg, H. B., Masson, N., Salah, E., Tumber, A., ... & Ratcliffe, P. J. (2022). Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6. Proceedings of the National Academy of Sciences, 119(32), e2201483119.

Wang, T., Zhang, R., Liu, Y., Fang, Z., Zhang, H., Fan, Y., ... & Xiang, R. (2021). Discovery of a new class of JMJD6 inhibitors and structure–activity relationship study. Bioorganic & Medicinal Chemistry Letters, 44, 128109.

Biswas, A., Mukherjee, G., Kondaiah, P., & Desai, K. V. (2020). Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer. BMC cancer, 20(1), 1-12.

Huo, D., Chen, H., Cheng, Y., Song, X., Zhang, K., Li, M. J., & Xuan, C. (2020). JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell Death & Differentiation, 27(3), 1052-1066.

Wong, M., Sun, Y., Xi, Z., Milazzo, G., Poulos, R. C., Bartenhagen, C., ... & Liu, T. (2019). JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nature Communications, 10(1), 3319.

Wan, J., Liu, H., Yang, L., Ma, L., Liu, J., & Ming, L. (2019). JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4. International Journal of Cancer, 144(10), 2489-2500.

Ran, T., Xiao, R., Huang, Q., Yuan, H., Lu, T., & Liu, W. (2019). In silico discovery of JMJD6 inhibitors for cancer treatment. ACS Medicinal Chemistry Letters, 10(12), 1609-1613.

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For research use only. Not intended for any clinical use.

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