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Mouse Anti-JMJD8 Recombinant Antibody (H-4) (CBMAB-0366-WJ)

This product is a mouse antibody that recognizes JMJD8. The antibody H-4 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all JMJD8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
H-4
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
jumonji domain containing 8
Introduction
JMJD8 (Jumonji Domain Containing 8) is a Protein Coding gene.
Entrez Gene ID
Human339123
Mouse72106
Rat360498
UniProt ID
HumanQ96S16
MouseQ3TA59
RatQ6AY40
Alternative Names
PP14397; C16orf20
Function
Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354).
Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445).
Biological Process
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of pyruvate kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum lumen; Cytoplasm
PTM
N-glycosylated.

Guo, J., & Zhao, J. (2024). USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1871(1), 119617.

Yi, J., Wang, L., Du, J., Wang, M., Shen, H., Liu, Z., ... & Liu, W. (2023). ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer. Developmental Cell, 58(9), 760-778.

Li, Y., Zhang, Y., Zhou, Z., Yi, L., Ji, F., Zhang, K., ... & Xu, H. (2023). JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation. Neuroscience Letters, 809, 137307.

You, D., Jung, B. C., Villivalam, S. D., Lim, H. W., & Kang, S. (2022). JMJD8 is a novel molecular nexus between adipocyte-intrinsic inflammation and insulin resistance. Diabetes, 71(1), 43-59.

Liang, X., Zhang, H., Wang, Z., Zhang, X., Dai, Z., Zhang, J., ... & Cheng, Q. (2022). JMJD8 is an M2 macrophage biomarker, and it associates with DNA damage repair to facilitate stemness maintenance, chemoresistance, and immunosuppression in Pan-cancer. Frontiers in Immunology, 13, 875786.

Wang, Y., Zhang, Y., Li, Z., & Wang, J. (2022). JMJD8 Functions as a Novel AKT1 Lysine Demethylase. International Journal of Molecular Sciences, 24(1), 460.

Zhang, B., Zhang, Y., Jiang, X., Su, H., Wang, Q., Wudu, M., ... & Qiu, X. (2021). JMJD8 promotes malignant progression of lung cancer by maintaining EGFR stability and EGFR/PI3K/AKT pathway activation. Journal of Cancer, 12(4), 976.

Su, Y., Wang, X., Guo, Z., & Wang, J. (2020). Aberrant JmjC domain-containing protein 8 (JMJD8) expression promotes activation of AKT and tumor epithelial–mesenchymal transition. Oncogene, 39(41), 6451-6467.

Su, Y., & Wang, J. (2019). JmjC domain-containing protein 8 (JMJD8) represses Ku70/Ku80 expression via attenuating AKT/NF-κB/COX-2 signaling. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(12), 118541.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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