Mouse Anti-JPT1 Recombinant Antibody (2C8) (CBMAB-A3983-LY)

Name: Mouse Anti-JPT1 Recombinant Antibody (2C8)
SKU: CBMAB-A3983-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2C8

Application

WB, ELISA

Immunogen

HN1 (AAH01420, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Jupiter microtubule associated homolog 1

Entrez Gene ID

51155

UniProt ID

Q9UK76

Alternative Names

ARM2; HN1A

Function

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408).
Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422).
Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365).
Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

Cellular Location

Nucleus; Cytoplasm

Chen, Y. Y., Luo, L. P., & Deng, K. C. (2023). Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity. Acta Biochimica Polonica, 70(1), 153-162.

Bateman, N. W., Teng, P. N., Hope, E., Hood, B. L., Oliver, J., Ao, W., ... & Conrads, T. P. (2020). Jupiter microtubule‐associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers. Cancer Medicine, 9(3), 1092-1103.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-JPT1 Recombinant Antibody (CBFYH-2601) (CAT#: CBMAB-H0580-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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