Rabbit Anti-JUND Recombinant Antibody (2HCLC) (CBMAB-0157-WJ)

Name: Rabbit Anti-JUND Recombinant Antibody (2HCLC)
SKU: CBMAB-0157-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

2HCLC

Application

ChIP, FC, ICC, IF, WB

Immunogen

Three synthetic peptides corresponding to human JunD

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

JunD proto-oncogene, AP-1 transcription factor subunit

Introduction

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms. Diseases associated with JUND include T-Cell Leukemia and Adult T-Cell Leukemia. Among its related pathways are Toll-like receptor signaling pathway and ERK Signaling. An important paralog of this gene is JUN.

Entrez Gene ID

3727

UniProt ID

P17535

Alternative Names

JUND; jun D proto-oncogene; transcription factor jun-D; activator protein 1; AP 1; JunD FL isoform; transcription factor jun D; JunD-FL isoform; AP-1

Function

Transcription factor binding AP-1 sites (PubMed:9989505).
Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:9989505, PubMed:28981703).

Biological Process

AgingIEA:Ensembl
Cellular response to calcium ionIEA:Ensembl
Circadian rhythmIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Osteoblast developmentIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:CAFA
Regulation of cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to light stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to mechanical stimulusIEA:Ensembl
Response to organic cyclic compoundIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl

Cellular Location

Nucleus

PTM

Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.

Zhou, J., Mo, J., Tan, C., Xie, F., Liang, J., & Huang, W. (2023). JUND Promotes Tumorigenesis via Specifically Binding on Enhancers of Multiple Oncogenes in Cervical Cancer. OncoTargets and Therapy, 347-357.

Ruiz, E. J., Lan, L., Diefenbacher, M. E., Riising, E. M., Da Costa, C., Chakraborty, A., ... & Behrens, A. (2021). JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI insight, 6(13).

Yang, H., Wang, J., Zhang, Z., Peng, R., Lv, D., Liu, H., & Sun, Y. (2021). Sp1-induced lncRNA Rmrp promotes mesangial cell proliferation and fibrosis in diabetic nephropathy by modulating the miR-1a-3p/JunD pathway. Frontiers in Endocrinology, 12, 690784.

Hussain, S., Khan, A. W., Akhmedov, A., Suades, R., Costantino, S., Paneni, F., ... & Cosentino, F. (2020). Hyperglycemia induces myocardial dysfunction via epigenetic regulation of JunD. Circulation research, 127(10), 1261-1273.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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