• Home
  • PRKACB
  • Rabbit Anti-PRKACB Recombinant Antibody (EG1739)

Rabbit Anti-PRKACB Recombinant Antibody (EG1739) (CBMAB-EN2077-LY)

See all PRKACB antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
EG1739
Application
WB: 1:500~1:1000 ELISA: 1:20000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human KAPCB.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
protein kinase cAMP-activated catalytic subunit beta
Introduction
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Entrez Gene ID
Human5567
Mouse18749
Rat293508
UniProt ID
HumanP22694
MouseP68181
RatP68182
Alternative Names
CAFD2; PKACB; PKA C-beta
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175).
Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
High-density lipoprotein particle assemblyTAS:Reactome
Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEA:Ensembl
Neural tube closureIEA:Ensembl
Protein kinase A signalingManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of protein processingIEA:Ensembl
Renal water homeostasisTAS:Reactome
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Cell membrane
Membrane
Nucleus
Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Involvement in disease
Cardioacrofacial dysplasia 2 (CAFD2):
An autosomal dominant disease characterized by dysmorphic facial features, congenital cardiac defects, primarily common atrium or atrioventricular septal defect, and limb anomalies, including short limbs, brachydactyly and postaxial polydactyly. CAFD2 patients may show developmental delay of variable severity, intellectual disability, autistic features and focal seizures.
PTM
Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-PRKACB Recombinant Antibody (EG1739)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PRKACB Recombinant Antibody (MM0866-26H42) (CAT#: CBMAB-C12222-LY)

Mouse Anti-PRKACB Recombinant Antibody (2G8-1D12) (CAT#: CBMAB-P2799-YC)

Mouse Anti-PRKACB Recombinant Antibody (CBYY-C2736) (CAT#: CBMAB-C4177-YY)

Mouse Anti-PRKACB Recombinant Antibody (1F8) (CAT#: CBMAB-A7033-LY)

Rabbit Anti-PRKACB Recombinant Antibody (CBWJC-4318) (CAT#: CBMAB-C5683WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry