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Mouse Anti-KAT6A Recombinant Antibody (CB33A) (CBMAB-CA033LY)

The product is antibody recognizes KAT6A. The antibody CB33A immunoassay techniques such as: ELISA, WB, IHC, ICC.
See all KAT6A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CB33A
Antibody Isotype
IgG
Application
ELISA, WB, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of Human MYST1 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Acetyltransferase 6A
Introduction
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Entrez Gene ID
7994
UniProt ID
Q92794
Alternative Names
Lysine Acetyltransferase 6A; Monocytic Leukemia Zinc Finger Protein; MYST Histone Acetyltransferase (Monocytic Leukemia) 3; Runt-Related Transcription Factor Binding Protein 2; MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 3; K(Lysine) Acetyltransferase 6A; Zinc Finger Protein 220; RUNXBP2; ZNF220; MYST-3;
Function
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Biological Process
Cellular senescenceManual Assertion Based On ExperimentIMP:UniProtKB
DNA packagingManual Assertion Based On ExperimentTAS:ProtInc
Histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Myeloid cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Nucleosome assemblyIEA:InterPro
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of signal transduction by p53 class mediatorTAS:Reactome
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body. Recruited into PML body after DNA damage.
Involvement in disease
Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP (PubMed:8782817). Translocation t(8;22)(p11;q13) with EP300 (PubMed:10824998). KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription (PubMed:11742995). Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation (PubMed:12676584).
Arboleda-Tham syndrome (ARTHS):
An autosomal dominant disorder characterized by intellectual disability, dysmorphic facial features, delayed psychomotor development, and lack of speech.
PTM
Autoacetylation at Lys-604 is required for proper function (By similarity).
Autoacetylated.
Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.
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For research use only. Not intended for any clinical use.

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