Mouse Anti-KCNA3 Recombinant Antibody (CBLY1-045) (CBMAB-K0475-LY)

Name: Mouse Anti-KCNA3 Recombinant Antibody (CBLY1-045)
SKU: CBMAB-K0475-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLY1-045

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium voltage-gated channel, shaker-related subfamily, member 3

Introduction

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	3738
Mouse	16491
Rat	29731

UniProt ID

Human	P22001
Mouse	P16390
Rat	P15384

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-234
Helical: 235-253
Extracellular: 254-294
Helical: 295-316
Cytoplasmic: 317-327
Helical: 328-348
Extracellular: 349-362
Helical: 363-381
Cytoplasmic: 382-397
Helical: 398-417
Extracellular: 418-458
Helical: 459-481
Cytoplasmic: 482-575

PTM

N-glycosylation promotes the cell surface expression.

Bian, Y., Gao, Y., Lu, C., Tian, B., Xin, L., Lin, H., ... & Wang, L. (2023). Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma. Chinese Medical Journal, 10-1097.

Lioudyno, V., Abdurasulova, I., Negoreeva, I., Stoliarov, I., Kudriavtsev, I., Serebryakova, M., ... & Lioudyno, M. (2021). A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis. Journal of Neuroscience Research, 99(1), 200-208.

Zhong, X., Lü, M., Wan, J., Zhou, T., & Qin, B. (2018). Long noncoding RNA kcna3 inhibits the progression of colorectal carcinoma through down-regulating YAP1 expression. Biomedicine & Pharmacotherapy, 107, 382-389.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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