Mouse Anti-KCNA4 Recombinant Antibody (S13-31) (CBMAB-K0481-LY)

Name: Mouse Anti-KCNA4 Recombinant Antibody (S13-31)
SKU: CBMAB-K0481-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S13-31

Application

WB, IHC-P, ICC/IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Voltage-Gated Channel Subfamily A Member 4

Introduction

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]

Entrez Gene ID

Human	3739
Mouse	16492
Rat	25469

UniProt ID

Human	P22459
Mouse	Q61423
Rat	P15385

Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559).
Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559).
Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).
Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Cell membrane; Cell projection, axon

Involvement in disease

Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum (MCIDDS):
An autosomal recessive syndrome characterized by cognitive impairment, attention deficit hyperactivity disorder, microcephaly, growth retardation, congenital cataract, and dystonia. Brain MRI shows unusual thinning of the lentiform nucleus, predominantly involving the putamen, and swelling in the caudate heads.

Topology

Cytoplasmic: 1-304
Helical: 305-326
Extracellular: 327-370
Helical: 371-392
Cytoplasmic: 393-403
Helical: 404-424
Extracellular: 425-439
Helical: 440-460
Cytoplasmic: 461-475
Helical: 476-497
Extracellular: 498-511
Helical: 512-531
Extracellular: 532-538
Helical: 539-567
Cytoplasmic: 568-653

Kang, G. J., Xie, A., Kim, E., & Dudley Jr, S. C. (2023). miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure. Heart Rhythm, 20(5), 730-736.

Gao, X., Yu, S., Guan, Y., Shen, Y., & Xu, L. (2021). Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity. Journal of cell science, 134(18), jcs256818.

Flecha-Velazquez, K., Fahey, T. D., Martínez, J. L., Lopez-Taylor, J. R., & Rivera, M. A. (2019). KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level. International Journal of Sports Medicine, 40(05), 354-358.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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