Mouse Anti-KCNAB3 Recombinant Antibody (S40-17) (CBMAB-P0415-YC)

Provided herein is a Mouse monoclonal antibody against Human Potassium voltage-gated channel subfamily A regulatory beta subunit 3. The antibody can be used for immunoassay techniques, such as IHC-Fr, ICC, IF, IP, WB.
See all KCNAB3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

S40-17

Antibody Isotype

IgG2a

Application

IHC-Fr, ICC, IF, IP, WB

Basic Information

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-401

Target

Full Name

potassium voltage-gated channel subfamily A regulatory beta subunit 3

Introduction

KCNAB3 is a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit.

Entrez Gene ID

Human	9196
Mouse	16499
Rat	58981

UniProt ID

Human	O43448
Mouse	P97382
Rat	Q63494

Alternative Names

KvBeta3

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.

Biological Process

Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

References

Ji, H. Y., Lin, Z. J., Chen, C., Xu, J. M., Yu, R., & Liu, L. (2023). Haploinsufficiency of KCNAB3 causes sudden cardiac death through delayed inactivation of Kv1. 5 channel upon depolarization and induced myocardial apoptosis. Genes & Diseases, 10(3), 671.

Ding, J., Wang, C., Huang, G. Q., Zhang, J. W., Zhai, Q. X., Chen, Z. H., ... & Guo, Y. X. (2022). Functional characterization of a KCNAB3 genetic epilepsy with febrile seizures plus adult mouse model. Translational Pediatrics, 11(10), 1615.

Ding, J., Miao, Q. F., Zhang, J. W., Guo, Y. X., Zhang, Y. X., Zhai, Q. X., & Chen, Z. H. (2020). H258R mutation in KCNAB3 gene in a family with genetic epilepsy and febrile seizures plus. Brain and Behavior, 10(12), e01859.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-KCNAB3 Recombinant Antibody (EG1746)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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