Mouse Anti-KCNB2 Recombinant Antibody (S37-89) (CBMAB-K0511-LY)

Name: Mouse Anti-KCNB2 Recombinant Antibody (S37-89)
SKU: CBMAB-K0511-LY
Rating: 5 (1 reviews)

See all KCNB2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S37-89

Application

IHC, IP, WB

Immunogen

Fusion protein amino acids 1-61 of rat Kv2.2

Specificity

Rat, Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Voltage-Gated Channel Subfamily B Member 2

Introduction

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	9312
Mouse	98741
Rat	117105

UniProt ID

Human	Q92953
Mouse	A6H8H5
Rat	Q63099

Alternative Names

Kv2.2

Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.

Biological Process

Potassium ion transmembrane transportISS:UniProtKB
Potassium ion transportISS:UniProtKB
Protein homooligomerizationIEA:InterPro
Protein localization to plasma membraneISS:UniProtKB
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Regulation of smooth muscle contractionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane; Perikaryon; Cell projection, dendrite. Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.

Topology

Cytoplasmic: 1-190
Helical: 191-212
Extracellular: 213-232
Helical: 233-254
Cytoplasmic: 255-265
Helical: 266-284
Extracellular: 285-296
Helical: 297-317
Cytoplasmic: 318-332
Helical: 333-354
Extracellular: 355-368
Helical: 369-388
Extracellular: 389-395
Helical: 396-424
Cytoplasmic: 425-911

PTM

Phosphorylated.

Yadav, P., Ahmed, T., Park, S., Sidler, M., Schröder, A., Aitken, K. J., & Bägli, D. (2023). EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells. American Journal of Clinical and Experimental Urology, 11(4), 293.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KCNB2 Recombinant Antibody (S37-89)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry