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Mouse Anti-KCNIP3 Recombinant Antibody (4H321) (CBMAB-D2092-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Potassium Voltage-Gated Channel Interacting Protein 3 (KCNIP3). The antibody can be used for immunoassay techniques, such as IP, WB.
See all KCNIP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H321
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Full length GST fusion protein of human Calsenilin/DREAM
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
potassium voltage-gated channel interacting protein 3
Introduction
KCNIP3 belongs to the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins.
Entrez Gene ID
30818
UniProt ID
Q9Y2W7
Alternative Names
Potassium Voltage-Gated Channel Interacting Protein 3; Calsenilin, Presenilin-Binding Protein, EF Hand Transcription Factor; A-Type Potassium Channel Modulatory Protein 3; Kv Channel Interacting Protein 3, Calsenilin; Kv Channel-Interacting Protein 3; DRE-Antagonist Modulator;
Function
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cell membrane; Endoplasmic reticulum; Golgi apparatus; Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870).
In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
PTM
Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).
Proteolytically cleaved by caspase-3.
Phosphorylation at Ser-63 inhibits cleavage by CASP3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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