Mouse Anti-KCNIP3 Recombinant Antibody (S66-38) (CBMAB-K0558-LY)

Name: Mouse Anti-KCNIP3 Recombinant Antibody (S66-38)
SKU: CBMAB-K0558-LY
Rating: 5 (1 reviews)

See all KCNIP3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S66-38

Application

IHC-Fr, IF, IP, WB

Immunogen

Fusion protein amino acids 1-256 (Full lenght) of rat Calsenillin/DREAM/KChIP3

Specificity

Rat, Mouse, Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium voltage-gated channel interacting protein 3

Introduction

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	30818
Mouse	56461
Rat	65199

UniProt ID

Human	Q9Y2W7
Mouse	Q9QXT8
Rat	Q9JM47

Alternative Names

Csen; Dream; rKChIP3

Function

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm; Cell membrane; Endoplasmic reticulum; Golgi apparatus; Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870).
In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.

PTM

Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).
Proteolytically cleaved by caspase-3.
Phosphorylation at Ser-63 inhibits cleavage by CASP3.

Zhong, J., Lin, R., Wang, G., Lin, L., Ruan, S., & Liu, W. (2022). KCNIP3 silence promotes proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma through activating Wnt/β-catenin pathway. Tissue and Cell, 75, 101739.

Guo, Y. P., Zhi, Y. R., Liu, T. T., Wang, Y., & Zhang, Y. (2019). Global gene knockout of Kcnip3 enhances pain sensitivity and exacerbates negative emotions in rats. Frontiers in molecular neuroscience, 12, 5.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KCNIP3 Recombinant Antibody (S66-38)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

KCNIP3 Matched Antibody Pair (657) (CAT#: APMAB-657LY)

Related Products

Rabbit Anti-KCNIP3 Recombinant Antibody (CBFYC-2855) (CAT#: CBMAB-C2931-FY)

Rabbit Anti-KCNIP3 Recombinant Antibody (CBFYC-2854) (CAT#: CBMAB-C2930-FY)

KCNIP3 Matched Antibody Pair (657) (CAT#: APMAB-657LY)

Mouse Anti-KCNIP3 Recombinant Antibody (2B3-A1) (CAT#: CBMAB-K0556-LY)

Rabbit Anti-KCNIP3 Recombinant Antibody (EG1757) (CAT#: CBMAB-EN2096-LY)

Mouse Anti-KCNIP3 Recombinant Antibody (4H321) (CAT#: CBMAB-D2092-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry