Mouse Anti-KCNU1 Recombinant Antibody (CBXS-2348) (CBMAB-S5107-CQ)

Name: Mouse Anti-KCNU1 Recombinant Antibody (CBXS-2348)
SKU: CBMAB-S5107-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2348

Application

ICC, WB

Immunogen

Fusion protein aa 1052-1121 of mouse Slo3 (accession number AAB99742)

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.09% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

potassium channel, subfamily U, member 1

Entrez Gene ID

16532

UniProt ID

G3X9P7

Alternative Names

Kcnma3; Slo3; mSlo3

Function

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Biological Process

Regulation of ion transmembrane transportIEA:UniProtKB-KW
Reproductive processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-24
Helical: 25-45
Cytoplasmic: 46-101
Helical: 102-122
Extracellular: 123-138
Helical: 139-159
Cytoplasmic: 160-163
Helical: 164-184
Extracellular: 185-188
Helical: 189-209
Cytoplasmic: 210-226
Helical: 227-247
Extracellular: 248-259
Pore-forming: 260-282
Extracellular: 283-291
Helical: 292-312
Cytoplasmic: 313-1149

Liu, R., Yan, Z., Fan, Y., Qu, R., Chen, B., Li, B., ... & Kuang, Y. (2022). Bi-allelic variants in KCNU1 cause impaired acrosome reactions and male infertility. Human Reproduction, 37(7), 1394-1405.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KCNU1 Recombinant Antibody (S2-16) (CAT#: CBMAB-K0065-LY)

Isotype control

For research use only. Not intended for any clinical use.

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