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Rabbit Anti-KCTD12 Recombinant Antibody (D8V4J) (CBMAB-CP1285-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D8V4J
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro177 of human KCTD12 protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Channel Tetramerization Domain Containing 12
Introduction
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Entrez Gene ID
Human115207
Mouse239217
UniProt ID
HumanQ96CX2
MouseQ6WVG3
Alternative Names
Potassium Channel Tetramerization Domain Containing 12; Predominantly Fetal Expressed T1 Domain; Potassium Channel Tetramerisation Domain Containing 12; C13orf2; PFETIN; PFET1;
Function
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Biological Process
Protein homooligomerizationIEA:InterPro
Cellular Location
Cell junction, synapse, presynaptic cell membrane; Cell junction, synapse, postsynaptic cell membrane
More Infomation

Ren, Y., Liu, Y., Zheng, S., & Luo, M. (2022). KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in Habenula Cholinergic Neurons. Journal of Neuroscience, 42(9), 1648-1665.

Zhang, C. W., Zhou, B., Liu, Y. C., Su, L. W., Meng, J., Li, S. L., & Wang, X. L. (2022). LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis. Environmental Toxicology, 37(8), 1853-1866.

Wang, Z., Wu, D., Dong, M., Xia, Y., & Xu, T. (2021). KCTD12 is a prognostic marker of breast cancer and correlates with tumor immune cell infiltration. Translational Cancer Research, 10(1), 261.

Deng, S. L., Hu, Z. L., Mao, L., Gao, B., Yang, Q., Wang, F., & Chen, J. G. (2021). The effects of Kctd12, an auxiliary subunit of GABAB receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice. Pharmacological Research, 163, 105355.

Ye, R. Y., Kuang, X. Y., Zeng, H. J., Shao, N., Lin, Y., & Wang, S. M. (2020). KCTD12 promotes G1/S transition of breast cancer cell through activating the AKT/FOXO1 signaling. Journal of Clinical Laboratory Analysis, 34(8), e23315.

Shen, W., Li, Y., Li, B., Zheng, L., Xie, X., Le, J., ... & Jia, L. (2019). Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271. Cancer biology & medicine, 16(3), 498.

Eszlari, N., Millinghoffer, A., Petschner, P., Gonda, X., Baksa, D., Pulay, A. J., ... & Juhasz, G. (2019). Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination. Translational psychiatry, 9(1), 119.

Abbaszadegan, M. R., Taghehchian, N., Li, L., Aarabi, A., & Moghbeli, M. (2018). Contribution of KCTD12 to esophageal squamous cell carcinoma. BMC cancer, 18(1), 1-7.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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