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Mouse Anti-KCTD5 Recombinant Antibody (3C8) (CBMAB-K0638-LY)

This product is antibody recognizes KCTD5. The antibody 3C8 immunoassay techniques such as: WB, FC, IHC, ICC/IF, IHC-P.
See all KCTD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C8
Antibody Isotype
IgG2b
Application
WB, FC, IHC, ICC/IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human KCTD5 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Channel Tetramerization Domain Containing 5
Introduction
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Entrez Gene ID
54442
UniProt ID
Q9NXV2
Alternative Names
Potassium Channel Tetramerization Domain Containing 5; Potassium Channel Tetramerisation Domain Containing 5;
Function
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101).
Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449).
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein homooligomerizationIEA:InterPro
Cellular Location
Cytoplasm, cytosol; Cytoplasm; Nucleus. Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

Jiang, W., Wang, W., Kong, Y., & Zheng, S. (2023). Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase. Science Advances, 9(28), eadg8369.

Liao, Y., Sloan, D. C., Widjaja, J. H., & Muntean, B. S. (2023). KCTD5 Forms Hetero-Oligomeric Complexes with Various Members of the KCTD Protein Family. International journal of molecular sciences, 24(18), 14317.

Shi, Y. X., Yan, J. H., Liu, W., & Deng, J. (2023). Identifies KCTD5 as a novel cancer biomarker associated with programmed cell death and chemotherapy drug sensitivity. BMC cancer, 23(1), 408.

Nguyen, D. M., Rath, D. H., Devost, D., Pétrain, D., Rizk, R., Ji, A. X., ... & Privé, G. G. (2023). Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex. bioRxiv, 2023-09.

Canales, J., Cruz, P., Díaz, N., Riquelme, D., Leiva-Salcedo, E., & Cerda, O. (2020). K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity. Cells, 9(10), 2273.

Rivas, J., Díaz, N., Silva, I., Morales, D., Lavanderos, B., Álvarez, A., ... & Cerda Arancibia, Ó. (2020). KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis.

Cho, H. J., Ryu, K. J., Baek, K. E., Lim, J., Kim, T., Song, C. Y., ... & Lee, H. G. (2020). Cullin 3/KCTD5 Promotes the ubiqutination of rho guanine nucleotide dissociation inhibitor 1 and regulates its stability. Journal of Microbiology and Biotechnology, 30(10), 1488.

He, H., Peng, Y., Fan, S., Chen, Y., Zheng, X., & Li, C. (2018). Cullin3/KCTD 5 induces monoubiquitination of ΔNp63α and impairs its activity. FEBS letters, 592(13), 2334-2340.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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