Mouse Anti-KCTD9 Recombinant Antibody (2G8) (CBMAB-K0643-LY)

Name: Mouse Anti-KCTD9 Recombinant Antibody (2G8)
SKU: CBMAB-K0643-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G8

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-223 of human KCTD9 (NP_060104) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium channel tetramerisation domain containing 9

Introduction

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Entrez Gene ID

54793

UniProt ID

Q7L273

Alternative Names

Potassium Channel Tetramerization Domain Containing 9; Potassium Channel Tetramerisation Domain Containing 9; BTB/POZ Domain-Containing Protein KCTD9; BTBD27;

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Biological Process

Intracellular signal transductionIEA:InterPro
Protein homooligomerizationIEA:InterPro
Protein ubiquitinationIEA:UniProtKB-UniPathway

Yao, H., Ren, D., Wang, Y., Wu, L., Wu, Y., Wang, W., ... & Liu, L. (2022). KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer. Cell Death & Disease, 13(9), 761.

Zhang, X., Wang, P., Chen, T., Yan, W., Guan, X., Shen, G., ... & Ning, Q. (2019). Kctd9 deficiency impairs natural killer cell development and effector function. Frontiers in Immunology, 10, 744.

Zhang, X., Zhu, L., Zhou, Y., Shi, A., Wang, H., Han, M., ... & Ning, Q. (2018). Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice. BMC immunology, 19(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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