Mouse Anti-KDM1A Recombinant Antibody (A746) (CBMAB-AP4075LY)

Lysine Demethylase 1A

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Lysine Demethylase 1A; Flavin-Containing Amine Oxidase Domain-Containing Protein 2; Amine Oxidase (Flavin Containing) Domain 2; BRAF35-HDAC Complex Protein BHC110; AOF2; KDM1; LSD1; FAD-Binding Protein BRAF35-HDAC Complex, 110 KDa Subunit; Lysine-Specific Histone Demethylase 1A;

CSB-MA581953

Alternative mRNA splicing, via spliceosomeIEA:Ensembl
Cellular response to cAMPIEA:Ensembl
Cellular response to gamma radiationManual Assertion Based On ExperimentIMP:MGI
Cellular response to UVManual Assertion Based On ExperimentIDA:MGI
Cerebral cortex developmentIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Guanine metabolic processIEA:Ensembl
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Muscle cell developmentBy SimilarityISS:BHF-UCL
Negative regulation of DNA binding1 PublicationIC:BHF-UCL
Negative regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of histone H3-K4 methylationISS:ARUK-UCL
Negative regulation of histone H3-K9 methylationISS:ARUK-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron maturationIEA:Ensembl
Positive regulation of cell sizeIEA:Ensembl
Positive regulation of chromatin bindingIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of histone ubiquitinationManual Assertion Based On ExperimentIMP:MGI
Positive regulation of neural precursor cell proliferationISS:ARUK-UCL
Positive regulation of neuroblast proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of neuron projection developmentIEA:Ensembl
Positive regulation of stem cell proliferationISS:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Protein demethylationManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of androgen receptor signaling pathwayTAS:Reactome
Regulation of DNA methylation-dependent heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:MGI
Regulation of protein localizationManual Assertion Based On ExperimentIMP:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Response to fungicideIEA:Ensembl

Nucleus

Cleft palate, psychomotor retardation, and distinctive facial features (CPRF):
A syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion.

Polyubiquitinated by JADE2; which leads to its proteasomal degradation.