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Mouse Anti-KDSR Recombinant Antibody (3E8) (CBMAB-A3236-LY)

The product is antibody recognizes FVT1. The antibody 3E8 immunoassay techniques such as: WB, ELISA.
See all KDSR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FVT1 (AAH08797.1, 12 a.a. ~ 332 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
3-ketodihydrosphingosine reductase
Introduction
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq]
Entrez Gene ID
2531
UniProt ID
Q06136
Alternative Names
DHSR; FLJ36555; FLJ92680; FVT1; SDR35C1
Function
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Biological Process
3-keto-sphinganine metabolic processManual Assertion Based On ExperimentIDA:MGI
Sphingolipid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region (PubMed:8417785).
Erythrokeratodermia variabilis et progressiva 4 (EKVP4):
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
Topology
Cytoplasmic: 26-270
Helical: 271-291
Lumenal: 292-293
Helical: 294-314
Cytoplasmic: 315-332
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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