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Mouse Anti-KHDRBS2 Recombinant Antibody (7G8C10) (CBMAB-K0803-LY)

This product is antibody recognizes KHDRBS2. The antibody 7G8C10 immunoassay techniques such as: ELISA, WB, IHC-P, IF/ICC, FC.
See all KHDRBS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
7G8C10
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF/ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human KHDRBS2 expressed in E. Coli
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.05% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KH RNA Binding Domain Containing, Signal Transduction Associated 2
Introduction
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Entrez Gene ID
Human202559
Mouse170771
UniProt ID
HumanQ5VWX1
MouseQ9WU01
Alternative Names
KH RNA Binding Domain Containing; Signal Transduction Associated 2; Sam68-Like Mammalian Protein 1; SLM-1; SLM1; KH Domain-Containing; RNA-Binding; Signal Transduction-Associated Protein 2; KH Domain Containing; RNA Binding; Signal Transduction Associated 2; HSLM-1;
Function
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).
Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Biological Process
mRNA processingIEA:UniProtKB-KW
Regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Methylated.
Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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