Mouse Anti-KHNYN Recombinant Antibody (CBLY1-076) (CBMAB-K0816-LY)

This product is antibody recognizes KHNYN. The antibody CBLY1-076 immunoassay techniques such as: WB, IP, IF, ELISA.
See all KHNYN antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLY1-076

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

KH And NYN Domain Containing

Introduction

This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Entrez Gene ID

23351

UniProt ID

O15037

Alternative Names

KH And NYN Domain Containing; KIAA0323; KH And NYN Domain-Containing Protein; Protein KHNYN;

Biological Process

RNA phosphodiester bond hydrolysis, endonucleolyticManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasmic ribonucleoprotein granule; Nucleus

References

Lista, M. J., Ficarelli, M., Wilson, H., Kmiec, D., Youle, R. L., Wanford, J., ... & Swanson, C. M. (2023). A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods. Journal of Virology, 97(1), e00872-22.

Lista, M. J., Galão, R. P., Ficarelli, M., Kmiec, D., Wilson, H., Winstone, H., ... & Swanson, C. M. (2021). Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking. bioRxiv, 2021-12.

Ficarelli, M., Wilson, H., Pedro Galão, R., Mazzon, M., Antzin-Anduetza, I., Marsh, M., ... & Swanson, C. M. (2019). KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides. Elife, 8, e46767.

Ficarelli, M., Wilson, H., Galão, R. P., Neil, S. J., & Swanson, C. M. (2019). KHNYN is essential for ZAP-mediated restriction of HIV-1 containing clustered CpG dinucleotides. bioRxiv, 581785.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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