Mouse Anti-KHNYN Recombinant Antibody (CBLY1-076) (CBMAB-K0816-LY)

Name: Mouse Anti-KHNYN Recombinant Antibody (CBLY1-076)
SKU: CBMAB-K0816-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLY1-076

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

KH And NYN Domain Containing

Introduction

This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Entrez Gene ID

23351

UniProt ID

O15037

Alternative Names

KH And NYN Domain Containing; KIAA0323; KH And NYN Domain-Containing Protein; Protein KHNYN;

Biological Process

RNA phosphodiester bond hydrolysis, endonucleolyticManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasmic ribonucleoprotein granule; Nucleus

Lista, M. J., Ficarelli, M., Wilson, H., Kmiec, D., Youle, R. L., Wanford, J., ... & Swanson, C. M. (2023). A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods. Journal of Virology, 97(1), e00872-22.

Lista, M. J., Galão, R. P., Ficarelli, M., Kmiec, D., Wilson, H., Winstone, H., ... & Swanson, C. M. (2021). Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking. bioRxiv, 2021-12.

Ficarelli, M., Wilson, H., Pedro Galão, R., Mazzon, M., Antzin-Anduetza, I., Marsh, M., ... & Swanson, C. M. (2019). KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides. Elife, 8, e46767.

Ficarelli, M., Wilson, H., Galão, R. P., Neil, S. J., & Swanson, C. M. (2019). KHNYN is essential for ZAP-mediated restriction of HIV-1 containing clustered CpG dinucleotides. bioRxiv, 581785.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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