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  • Mouse Anti-KIF1C Recombinant Antibody (1F12)

Mouse Anti-KIF1C Recombinant Antibody (1F12) (CBMAB-K0851-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
1F12
Application
ELISA, IHC-P, WB
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
kinesin family member 1C
Introduction
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]
Entrez Gene ID
10749
UniProt ID
O43896
Alternative Names
Kinesin Family Member 1C; Spastic Ataxia 2 (Autosomal Recessive); Kinesin-Like Protein KIF1C; KIAA0706; LTXS1; SATX2; SPAX2; SPG58; SAX2;
Function
Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Biological Process
Anterograde neuronal dense core vesicle transportISS:ARUK-UCL
Cytoskeleton-dependent intracellular transportManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Retrograde neuronal dense core vesicle transportISS:ARUK-UCL
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentTAS:ProtInc
Vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Involvement in disease
Spastic ataxia 2, autosomal recessive (SPAX2):
A neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
PTM
Phosphorylated on tyrosine residues.

Nagel, M., Noß, M., Xu, J., Horn, N., Ueffing, M., Boldt, K., & Schüle, R. (2023). The kinesin motor KIF1C is a putative transporter of the exon junction complex in neuronal cells. RNA, 29(1), 55-68.

Norris, M. L., & Mendell, J. T. (2023). Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Genes & development.

Saji, T., Nishita, M., Ikeda, K., Endo, M., Okada, Y., & Minami, Y. (2022). c-Src–mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells. Journal of Biological Chemistry, 298(7).

Siddiqui, N., Roth, D., Toleikis, A., Zwetsloot, A. J., Cross, R. A., & Straube, A. (2022). Force generation of KIF1C is impaired by pathogenic mutations. Current Biology, 32(17), 3862-3870.

Pichon, X., Moissoglu, K., Coleno, E., Wang, T., Imbert, A., Robert, M. C., ... & Mili, S. (2021). The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions. Rna, 27(12), 1528-1544.

Kobayakawa, M., Matsubara, T., Mizokami, A., Hiura, F., Takakura, N., Kokabu, S., ... & Jimi, E. (2020). Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas. Cell Biochemistry and Function, 38(3), 300-308.

Siddiqui, N., Zwetsloot, A. J., Bachmann, A., Roth, D., Hussain, H., Brandt, J., ... & Straube, A. (2019). PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport. Nature communications, 10(1), 2693.

Kendrick, A. A., Dickey, A. M., Redwine, W. B., Tran, P. T., Vaites, L. P., Dzieciatkowska, M., ... & Reck-Peterson, S. L. (2019). Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. Journal of Cell Biology, 218(9), 2982-3001.

Marchionni, E., Méneret, A., Keren, B., Melki, J., Denier, C., Durr, A., ... & Mochel, F. (2019). KIF1C variants are associated with hypomyelination, ataxia, tremor, and dystonia in fraternal twins. Tremor and Other Hyperkinetic Movements, 9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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