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Rabbit Anti-KIF2A Recombinant Antibody (CBLY1-084) (CBMAB-K0873-LY)

This product is antibody recognizes KIF2A. The antibody CBLY1-084 immunoassay techniques such as: WB, IHC-P, ICC/IF.
See all KIF2A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLY1-084
Antibody Isotype
IgG
Application
WB, IHC-P, ICC/IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Family Member 2A
Introduction
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Entrez Gene ID
3796
UniProt ID
O00139
Alternative Names
Kinesin Family Member 2A; Kinesin-2; KIF2; HK2; Kinesin Heavy Chain Member 2A; Kinesin Heavy Chain Member 2;
Function
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Microtubule depolymerizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Regulation of cell migrationManual Assertion Based On ExperimentIGI:ARUK-UCL
Cellular Location
Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
Involvement in disease
Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3):
A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset epilepsy, and various malformations of cortical development such as agyria, posterior or frontal pachygyria, subcortical band heterotopia, and thin corpus callosum.

Bai, F., He, Z., Zhou, H., & Gan, W. (2022). Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer. Journal of Clinical Laboratory Analysis, 36(5), e24313.

Chen, J., Wen, J., Liu, D., Xu, X., Fan, M., & Zhang, Z. (2022). The molecular mechanism of kinesin family member 2A (KIF2A) underlying non-small cell lung cancer: the effect of its knockdown on malignant behaviors, stemness, chemosensitivity, and potential regulated signaling pathways. American Journal of Translational Research, 14(1), 68.

Liang, X., & Xia, R. (2022). Kinesin family member 2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia. Oncology Reports, 47(1), 1-13.

Zhang, X., Wu, M., Peng, G., Li, W., Guo, Z., Li, H., & Jiang, M. (2022). Aberrant kinesin family member 2A signifies tumor size and invasion, and may help predict prognosis of patients with papillary thyroid carcinoma. Oncology Letters, 24(2), 1-7.

Xu, L., Zhang, X., Wang, Z., Zhao, X., Zhao, L., & Hu, Y. (2021). Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer. American Journal of Translational Research, 13(4), 2060.

Lei, G., Xin, X., & Hu, X. (2021). Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients. Irish Journal of Medical Science (1971-), 1-6.

Wang, Z. X., Ren, S. C., Chang, Z. S., & Ren, J. (2020). Identification of kinesin family member 2A (KIF2A) as a promising therapeutic target for osteosarcoma. BioMed research international, 2020.

Wang, G., Wang, Z., & Yu, H. (2020). Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients. Journal of Clinical Laboratory Analysis, 34(4), e23135.

Ding, T., Li, J., Sun, J., Fan, X., Shi, C., Zhou, D., & Deng, R. (2020). Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia. Brazilian Journal of Medical and Biological Research, 54.

Li, D., Sun, H., Meng, L., & Li, D. (2020). RETRACTED ARTICLE: The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma. Cancer Management and Research, 3731-3739.

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For research use only. Not intended for any clinical use.

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