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Mouse Anti-KIF9 Recombinant Antibody (4E9) (CBMAB-K0898-LY)

This product is antibody recognizes KIF9. The antibody 4E9 immunoassay techniques such as: ELISA, WB.
See all KIF9 antibodies
Published Data
Fig.1 Kif9 localizes to the mitotic spindle, and its expression is necessary for Gem-induced spindle length phenotype.
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Fig.2 Kif9 associates with Gem.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E9
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
KIF9 (NP_878905.1, 691 a.a. ~ 789 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: VDQCRHRLLM EFDIWYNESF VIPEDMQMAL KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL QQRVLPEGPD SISFYNAKVK IEQKHNYLKT MMGLQQAHR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kinesin family member 9
Introduction
KIF9 (Kinesin Family Member 9) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule binding. An important paralog of this gene is KIF6.
Entrez Gene ID
64147
UniProt ID
Q9HAQ2
Alternative Names
Kinesin Family Member 9;
Function
Essential for normal male fertility and for progressive motility of spermatozoa.
Biological Process
Extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Organelle disassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of flagellated sperm motilityISS:UniProtKB
Regulation of podosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, flagellum axoneme

Konjikusic, M. J., Lee, C., Yue, Y., Shrestha, B. D., Nguimtsop, A. M., Horani, A., ... & Wallingford, J. B. (2023). Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes. Journal of cell science, 136(5), jcs259535.

Meng, Z., Meng, Q., Gao, T., Zhou, H., Xue, J., Li, H., ... & Lv, J. (2023). Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families. Frontiers in Endocrinology, 13, 1091107.

Yu, Y., Lu, X., Yan, Y., Wang, Y., Meng, J., Tian, S., & Mu, J. (2022). The lncRNA KIF9-AS1 accelerates hepatocellular carcinoma growth by recruiting DNMT1 to promote RAI2 DNA methylation. Journal of Oncology, 2022.

Miyata, H., Oyama, Y., Kaneda, Y., & Ikawa, M. (2022). The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum. Experimental Animals, 71(1), 46-52.

Yao, J., Gao, R., Luo, M., Li, D., Guo, L., Yu, Z., ... & Wang, L. (2021). Long noncoding RNA KIF9-AS1 promotes cell apoptosis by targeting the microRNA-148a-3p/suppressor of cytokine signaling axis in inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 33(Suppl 1), e922.

Miyata, H., Shimada, K., Morohoshi, A., Oura, S., Matsumura, T., Xu, Z., ... & Ikawa, M. (2020). Testis‐enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa. The FASEB Journal, 34(4), 5389-5400.

Jin, Y., Huang, R., Xia, Y., Huang, C., Qiu, F., Pu, J., ... & Zhao, X. (2020). Long noncoding RNA KIF9-AS1 regulates transforming growth factor-β and autophagy signaling to enhance renal cell carcinoma chemoresistance via microRNA-497-5p. DNA and cell biology, 39(7), 1096-1103.

You, H., Wang, S., & Yu, S. (2020). KIF9‑AS1 promotes nasopharyngeal carcinoma progression by suppressing miR‑16. Oncology Letters, 20(5), 1-1.

Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., & Zeng, L. (2018). KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Molecular medicine reports, 17(2), 2195-2202.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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